Fig. 8

A Mitochondrial, endosomal and nuclear distribution of DOX in MDA-435/LCC6^WT and MDA-435/LCC6^MDR cells after internalization of pH-sensitive DOX–polymer conjugates: Pink color shows localization of DOX (red) in nucleus (blue), while yellow color is an indication of localization of DOX (red) in mitochondria (green) or endo/lysosomes. Curves showing mice survival and tumor size evolution for mice treated with DOX–polymer conjugates versus other groups [208]. B Photographs of phase transitions of PAEU–PEG–PAEU copolymers with respect to pH or temperature, and hGH concentration in blood of SD rats after injection of hGH solution, and hGH-gel formulation [256]. C Scheme depicting concept of pH-responsive PMPC–PDPA vesicles used for gene transfection and the cell viability assay and enhanced GFP expression [234]