Fig. 7
From: Assessment of Protein Entrapment in Hydroxyapatite Scaffolds by Size Exclusion Chromatography
Sketch depicting the role of texture in a material with regards to the adsorption and retention of proteins. It is assumed the continuous flushing of a mixture of proteins at the surface of a material. Proteins have different sizes, relative concentrations and affinities for the substrate. It is clearly observed that in spite of the fact that the protein in white colour has greater affinity for the substrate a the particular topography of the material might reduce b and even impede c its adsorption. Furthermore, textures presenting constricted spaces favour protein entrapment rendering, in turn, surfaces with a high content of entrapped/retained proteins (b and c)