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Journal for Biophysical Chemistry

Monitoring kinetics of surface initiated atom transfer radical polymerization by quartz crystal microbalance with dissipation


This article reports that the kinetics of surface-initiated atom transfer radical polymerization can be quantified by the quartz crystal microbalance with dissipation (QCM-D) technique. The kinetics of in situ growth of poly(oligoethylene glycol methylmethacrylate) monitored on a gold-coated QCM-D sensor chip revealed that changes in the experimentally observed frequency (ΔF) and dissipation (ΔD) as a function of polymerization time were a function of the initiator density, and that the experimental response could be predicted from a continuum model.


  1. J. Pyun, T. Kowalewski, and K. Matyjaszewski, Macromol. Rapid Commun. 24, 1043 (2003).

    Article  CAS  Google Scholar 

  2. Polymer Brushes: Synthesis, Characterization, Applications, edited by R. C. Advincula, W. J. Brittain, K. C. Caster, and J. Ruhe (Wiley-VCH, Weinheim, 2004).

  3. G. K. Jennings and E. L. Brantley, Adv. Mater. (Weinheim, Ger.) 16, 1983 (2004).

    Article  CAS  Google Scholar 

  4. S. Edmondson, V. L. Osborne, and W. T. S. Huck, Chem. Soc. Rev. 33, 14 (2004).

    Article  CAS  Google Scholar 

  5. D. J. Li, X. Sheng, and B. Zhao, J. Am. Chem. Soc. 127, 6248 (2005).

    Article  CAS  Google Scholar 

  6. O. Prucker and J. Ruhe, Macromolecules 31, 602 (1998).

    Article  CAS  Google Scholar 

  7. F. Hook, A. Ray, B. Norden, and B. Kasemo, Langmuir 17, 8305 (2001).

    Article  Google Scholar 

  8. M. Rodahl, F. Hook, and B. Kasemo, Anal. Chem. 68, 2219 (1996).

    Article  CAS  Google Scholar 

  9. M. Rodahl, F. Hook, A. Krozer, P. Brzezinski, and B. Kasemo, Rev. Sci. Instrum. 66, 3924 (1995).

    Article  CAS  Google Scholar 

  10. H. Ma, M. Wells, T. P. Beebe, Jr., and A. Chilkoti, Adv. Funct. Mater. 16, 640 (2005).

    Article  Google Scholar 

  11. H. Ma, J. Hyun, P. Stiller, and A. Chilkoti, Adv. Funct. Mater. 16, 338 (2004).

    CAS  Google Scholar 

  12. F. Hook, B. Kasemo, T. Nylander, C. Fant, K. Sott, and H. Elwing, Anal. Chem. 73, 5796 (2001).

    Article  CAS  Google Scholar 

  13. M. V. Voinova, M. Rodahl, M. Jonson, and B. Kasemo, Phys. Scr. 59, 391 (1999).

    Article  CAS  Google Scholar 

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Correspondence to Ashutosh Chilkoti.

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Ma, H., Textor, M., Clark, R.L. et al. Monitoring kinetics of surface initiated atom transfer radical polymerization by quartz crystal microbalance with dissipation. Biointerphases 1, 35–39 (2006).

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