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Biointerphases

Journal for Biophysical Chemistry

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Nanosized particles in bone and dissolution insensitivity of bone mineral

Biointerphases volume 1, pages 106–111 (2006)Cite this article

Abstract

Most of the mineral crystals in bone are platelets of carbonated apatite with thicknesses of a few nanometers embedded in a collagen matrix.We report that spherical to cylindrical shaped nanosized particles are also an integral part of bone structure observed by high resolution scanning electron microscopy. High resolution back scattered electron imaging reveals that the spherical particles have a contrast similar to the crystal platelets, suggesting that they are thus likely to have similar mineral properties. By means of constant composition (CC) dissolution of bone, similar sized nanoparticles are shown to be insensitive to demineralization and are thought to be dynamically stabilized due to the absence of active pits/defects on the crystallite surfaces. Similar reproducible self-inhibited dissolution was observed with these nanoparticles during CC dissolution of synthetic carbonated apatite. This result rules out the possible influence of complicating biological factors such as the possible presence of organic matrix components and other impurities. This phenomenon can be explained by a unique dissolution model involving size considerations at the nanoscale. The unexpected presence of nanoparticles in mature bone may also be due to the stabilization of some nanosized particles during the formation process in a fluctuating biological milieux.

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Authors and Affiliations

  1. Department of Chemistry, University at Buffalo, The State University of New York, 14260, Buffalo, New York

    Lijun Wang, George H. Nancollas & Zachary J. Henneman

  2. Department of Research Support, Weizmann Institute of Science, 76100, Rehovot, Israel

    Eugenia Klein

  3. Department of Structural Biology, Weizmann Institute of Science, 76100, Rehovot, Israel

    Steve Weiner

Authors
  1. Lijun Wang
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  2. George H. Nancollas
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  3. Zachary J. Henneman
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  4. Eugenia Klein
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  5. Steve Weiner
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These authors contributed equally to this work.

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Wang, L., Nancollas, G.H., Henneman, Z.J. et al. Nanosized particles in bone and dissolution insensitivity of bone mineral. Biointerphases 1, 106–111 (2006). https://doi.org/10.1116/1.2354575

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  • DOI: https://doi.org/10.1116/1.2354575