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Journal for Biophysical Chemistry

Biointerphases Cover Image

Nanomaterials and nanoparticles: Sources and toxicity

Abstract

This review is presented as a common foundation for scientists interested in nanoparticles, their origin, activity, and biological toxicity. It is written with the goal of rationalizing and informing public health concerns related to this sometimes-strange new science of “nano,” while raising awareness of nanomaterials’ toxicity among scientists and manufacturers handling them. We show that humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and that our bodily systems are well adapted to protect us from these potentially harmful intruders. The reticuloendothelial system, in particular, actively neutralizes and eliminates foreign matter in the body, including viruses and nonbiological particles. Particles originating from human activities have existed for millennia, e.g., smoke from combustion and lint from garments, but the recent development of industry and combustion-based engine transportation has profoundly increased anthropogenic particulate pollution. Significantly, technological advancement has also changed the character of particulate pollution, increasing the proportion of nanometer-sized particles-“nanoparticles”-and expanding the variety of chemical compositions. Recent epidemiological studies have shown a strong correlation between particulate air pollution levels, respiratory and cardiovascular diseases, various cancers, and mortality. Adverse effects of nanoparticles on human health depend on individual factors such as genetics and existing disease, as well as exposure, and nanoparticle chemistry, size, shape, agglomeration state, and electromagnetic properties. Animal and human studies show that inhaled nanoparticles are less efficiently removed than larger particles by the macrophage clearance mechanisms in the lungs, causing lung damage, and that nanoparticles can translocate through the circulatory, lymphatic, and nervous systems to many tissues and organs, including the brain. The key to understanding the toxicity of nanoparticles is that their minute size, smaller than cells and cellular organelles, allows them to penetrate these basic biological structures, disrupting their normal function. Examples of toxic effects include tissue inflammation, and altered cellular redox balance toward oxidation, causing abnormal function or cell death. The manipulation of matter at the scale of atoms, “nanotechnology,” is creating many new materials with characteristics not always easily predicted from current knowledge. Within the nearly limitless diversity of these materials, some happen to be toxic to biological systems, others are relatively benign, while others confer health benefits. Some of these materials have desirable characteristics for industrial applications, as nanostructured materials often exhibit beneficial properties, from UV absorbance in sunscreen to oil-less lubrication of motors. A rational science-based approach is needed to minimize harm caused by these materials, while supporting continued study and appropriate industrial development. As current knowledge of the toxicology of “bulk” materials may not suffice in reliably predicting toxic forms of nanoparticles, ongoing and expanded study of “nanotoxicity” will be necessary. For nanotechnologies with clearly associated health risks, intelligent design of materials and devices is needed to derive the benefits of these new technologies while limiting adverse health impacts. Human exposure to toxic nanoparticles can be reduced through identifying creation-exposure pathways of toxins, a study that may someday soon unravel the mysteries of diseases such as Parkinson’s and Alzheimer’s. Reduction in fossil fuel combustion would have a large impact on global human exposure to nanoparticles, as would limiting deforestation and desertification. While nanotoxicity is a relatively new concept to science, this review reveals the result of life’s long history of evolution in the presence of nanoparticles, and how the human body, in particular, has adapted to defend itself against nanoparticulate intruders.

Abbreviations

μm:

micrometer

1D:

One Dimensional

2D:

Two Dimensional

3D:

Three Dimensional

AFM:

Atomic Force Microscopy

AQI:

Air Quality Index

CNTs:

Carbon NanoTubes

DNA:

DeoxyriboNucleic Acid

EDS:

Energy Dispersive Spectrometry

EPA:

Environmental Protection Agency

GLAD:

Glancing Angle Deposition

HIV:

Human Immunodeficiency Virus

MISR:

Multi-angle Imaging SpectroRadiometer

MODIS:

MODerate-resolution Imaging Spectroradiometer

MWCNTs:

Multiple-Wall Carbon NanoTubes

NASA:

National Aeronautics and Space Administration

nm:

nanometer

PM:

Particulate Matter

ROS:

Reactive Oxygen Species

SEM:

Scanning Electron Microscopy

SWCNs:

Single-Wall Carbon Nanotubes

TEM:

Transmission Electron Microscope

References

  1. 1

    R. F. Jarrett, J. Pathol. 208, 176 (2006).

    CAS  Article  Google Scholar 

  2. 2

    D. DiMaio and J. B. Liao, Adv. Virus Res. 66, 125 (2006).

    CAS  Article  Google Scholar 

  3. 3

    M. Levrero, Oncogene 25, 3834 (2006).

    CAS  Article  Google Scholar 

  4. 4

    J. G. Kusters, A. H. van Vliet, and E. J. Kuipers, Clin. Microbiol. Rev. 19, 449 (2006).

    CAS  Article  Google Scholar 

  5. 5

    J. S. Burgos, Med. Oncol. 22, 113 (2005).

    CAS  Article  Google Scholar 

  6. 6

    E. O. Kajander and N. Çiftçioglu, Proc. Natl. Acad. Sci. U.S.A. 95, 8274 (1998).

    CAS  Article  Google Scholar 

  7. 7

    J. S. Kahn, Curr. Opin. Pediatr. 18, 42 (2006).

    Google Scholar 

  8. 8

    A. Kol and M. Santini, Ital. Heart J 5, 350 (2004).

    Google Scholar 

  9. 9

    J. Fohlman and G. Friman, Ann. Med. 25, 569 (1993).

    CAS  Google Scholar 

  10. 10

    R. F. Itzhaki, M. A. Wozniak, D. M. Appelt, and B. J. Balin, Neurobiol. Aging 25, 619 (2004).

    CAS  Article  Google Scholar 

  11. 11

    N. E. Lynch, S. Deiratany, D. W. Webb, and J. B. McMenamin, Ir Med. J. 100, 155 (2006).

    Google Scholar 

  12. 12

    H. C. Miranda, S. O. Nunes, E. S. Calvo, S. Suzart, E. N. Itano, and M.A. Watanabe, J. Affect Disord. 90, 43 (2006).

    CAS  Article  Google Scholar 

  13. 13

    J. Janka and F. Maldarelli, Curr. Infect. Dis. Rep 6, 305 (2004).

    Article  Google Scholar 

  14. 14

    http://www.nanotechproject.org/index.php?id=44

  15. 15

    Consumer Reports, July 2007, pp. 40-45, www.ConsumerReports.org

  16. 16

    R. P. Feynman, http://www.zyvex.com/nanotech/feynman.html

  17. 17

    B. Kittelson, Proceedings of the Conference on Current Research on Diesel Exhaust Particles of the Japan Association of Aerosol Science and Technology, Tokyo, 9 January 2001 (unpublished), and references therein.

  18. 18

    P. J. A. Borm et al., Part. Fibre Toxicol 3, 11 (2006).

    Article  CAS  Google Scholar 

  19. 19

    K. Donaldson, V. Stone, C. Tran, W. Kreyling, and P. J. A. Borm, Occup. Environ. Med. 61, 727 (2004), and references therein.

    CAS  Article  Google Scholar 

  20. 20

    G. Oberdörster, E. Oberdörster, and J. Oberdörster, Environ. Health Perspect. 113, 823 (2005); http://www.ehponline.org/members/2005/7339/7339.html

    Article  CAS  Google Scholar 

  21. 21

    Public Health Image Library, http://phil.cdc.gov/Phil/home.asp

  22. 22

    Jim Ekstrom, http://science.exeter.edu/jekstrom/SEM/SEM.html

  23. 23

    W. R. Hansen and K. Autumn, Proc. Natl. Acad. Sci. U.S.A. 102, 385 (2005).

    CAS  Article  Google Scholar 

  24. 24

    C. Sioutas, R. J. Delfino, and M. Singh, Environ. Health Perspect. 113, 947 (2005), and references therein.

    Article  Google Scholar 

  25. 25

    www.visualsunlimited.com

  26. 26

    University of Illinois at Urbana-Champaign, College of Medicine, https://histo.life.uiuc.edu/histo/atlas/index.php

  27. 27

    E. Roduner, Chem. Soc. Rev. 35, 583 (2006).

    CAS  Article  Google Scholar 

  28. 28

    L. P. Kouwenhoven, D. G. Austing, and S. Tarucha, Rep. Prog. Phys. 64, 701 (2001).

    CAS  Article  Google Scholar 

  29. 29

    ISI web of science http://portal.isiknowledge.com/

  30. 30

    P. H. M. Hoet, I. Bruske-Hohlfeld, and O. V. Salata, J. Nanobiotechnol 2, 12 (2004), and references therein.

    Article  CAS  Google Scholar 

  31. 31

    A. D. Maynard and E. D. Kuempel, J. Nanopart. Res. 7, 587 (2005).

    CAS  Article  Google Scholar 

  32. 32

    A. Nel, T. Xia, L. Madler, and N. Li, Science 311, 622 (2006).

    CAS  Article  Google Scholar 

  33. 33

    N. Kunzli and I. B. Tager, Schweiz Med. Wochenschr 135, 697 (2005).

    CAS  Google Scholar 

  34. 34

    N. Englert, Toxicol. Lett. 149, 235 (2004).

    CAS  Article  Google Scholar 

  35. 35

    R. J. Delfino, C. Sioutas, and S. Malik, Environ. Health Perspect. 113, 934 (2005).

    Article  Google Scholar 

  36. 36

    C. Ostiguy, G. Lapointe, L. Menard, Y. Cloutier, M. Trottier, M. Boutin, M. Antoun, and C. Normans, Report No. R-470 (www.irsst.qc.ca).

  37. 37

    J. Ferin, Toxicol. Lett. 72, 121 (2004), and references therein.

    Article  Google Scholar 

  38. 38

    G. Oberdorster, Int. Arch. Occup. Environ. Health 74, 1 (2001).

    CAS  Article  Google Scholar 

  39. 39

    G. Oberdörster, Inhalation Toxicol. 14, 29 (2002), and references therein.

    Article  Google Scholar 

  40. 40

    P. J. A. Borm, R. P. F. Schins, and C. Albrecht, Int. J. Cancer 110, 3 (2004), and references therein.

    CAS  Article  Google Scholar 

  41. 41

    A. M. Knaapen, P. J. A. Borm, C. Albrecht, and R. P. F. Schins, Int. J. Cancer 109, 799 (2004).

    CAS  Article  Google Scholar 

  42. 42

    K. Donaldson, L. Tran, L. A. Jimenez, R. Duffin, D. E. Newby, N. Mills, W. MacNee, and V. Stone, Part. Fibre Toxicol. 2, 10 (2005).

    Article  CAS  Google Scholar 

  43. 43

    R. C. Brown, A. H. Lockwook, and B. R. Sonowana, Environ. Health Perspect. 113, 1250 (2005), and references therein.

    CAS  Article  Google Scholar 

  44. 44

    A. Churg, Free Radic Biol. Med. 34, 1230 (2003).

    CAS  Article  Google Scholar 

  45. 45

    K. Donaldson et al., Free Radic Biol. Med. 34, 1369 (2003).

    CAS  Article  Google Scholar 

  46. 46

    B. Gonzales-Flecha, Mol. Aspects Med. 25, 169 (2004).

    Article  CAS  Google Scholar 

  47. 47

    L. Risom, P. Moller, and S. Loft, Mutat Res. 592, 119 (2005), and references therein.

    CAS  Article  Google Scholar 

  48. 48

    F. Tao, B. Gonzales-Flecha, and L. Kobzik, Free Radic Biol. Med. 35, 327 (2003).

    CAS  Article  Google Scholar 

  49. 49

    A. Peters, Toxicol. Appl. Pharmacol. 207, S477 (2005), and references therein.

    Article  CAS  Google Scholar 

  50. 50

    K. Donaldson and V. Stone, Ann. Ist Super Sanita 39, 405 (2003), and references therein.

    CAS  Google Scholar 

  51. 51

    B. Fubini and A. Hubbard, Free Radic Biol. Med. 34, 1507 (2003).

    CAS  Article  Google Scholar 

  52. 52

    N. Hussain, V. Jaitley, and A. T. Florence, Adv. Drug Delivery Rev. 50, 107 (2001).

    CAS  Article  Google Scholar 

  53. 53

    S. M. Moghimi, A. C. Hunter, and J. C. Murray, FASEB J. 19, 311 (2005).

    CAS  Article  Google Scholar 

  54. 54

    K. W. Powers, S. C. Brown, V. B. Krishna, S. C. Wasdo, B. M. Moudgil, and S. M. Roberts, Toxicol. Sci. 90, 296 (2006).

    CAS  Article  Google Scholar 

  55. 55

    G. Oberdörster et al., Part. Fibre Toxicol. 2, 8 (2005).

    Article  CAS  Google Scholar 

  56. 56

    T. Thomas, K. Thomas, N. Sadrieh, N. Savage, P. Adair, and R. Bronaugh, Toxicol. Sci. 91, 14 (2006).

    CAS  Article  Google Scholar 

  57. 57

    V. L. Colvin, Nat. Biotechnol. 21, 1166 (2003).

    CAS  Article  Google Scholar 

  58. 58

    E. E. Connor, J. Mwamuka, A. Gole, C. J. Murphy, and M. D. Wyatt, Small 1, 325 (2005).

    CAS  Article  Google Scholar 

  59. 59

    C. M. Goodman, C. D. McCusker, T. Yilmaz, and V. Rotello, Bioconjugate Chem. 15, 897 (2004).

    CAS  Article  Google Scholar 

  60. 60

    A. M. Derfus, W. C. W. Chan, and S. N. Bhatia, Nano Lett. 4, 11 (2004).

    CAS  Article  Google Scholar 

  61. 61

    S. Bosi, T. da Ros, G. Spalluto, and M. Prato, Eur. J. Med. Chem. 38, 913 (2003), and references therein.

    CAS  Article  Google Scholar 

  62. 62

    D. Schubert, R. Dargusch, J. Raitano, and S. W. Chan, Biochem. Biophys. Res. Commun. 342, 86 (2006).

    CAS  Article  Google Scholar 

  63. 63

    Handbook of Thin-Film Deposition Processes and Techniques- Principles, Methods, Equipment and Applications, edited by K. Seshan (Andrew, /Noyes,, 2002), pp. 1-657.

  64. 64

    K. Robbie, J. Yang, C. Elliott, R. Dariani, and C. Buzea (unpublished).

  65. 65

    D. A. Taylor, Environ. Health Perspect. 110, A80 (2002).

    Article  Google Scholar 

  66. 66

    J. Houghton, Rep. Prog. Phys. 68, 1343 (2005).

    Article  Google Scholar 

  67. 67

    P. R. Buseck and M. Pósfai, Proc. Natl. Acad. Sci. U.S.A. 96, 3372 (1999), and references therein.

    CAS  Article  Google Scholar 

  68. 68

    Z. Shi, L. Shao, T. P. Jones, and S. Lu, J. Geophys. Res. 110, D01303 (2005), and references therein.

    Article  CAS  Google Scholar 

  69. 69

    G. A. d’Almeida and L. Schutz, J. Clim. Appl. Meteorol. 22, 233 (1983).

    Article  Google Scholar 

  70. 70

    R. B. Husar et al., J. Geophys. Res. 106, 18317 (2001).

    CAS  Article  Google Scholar 

  71. 71

    I. G. McKendry, J. P. Hacker, R. Stull, S. Sakiyama, D. Mignacca, and K. Reid, J. Geophys. Res. 106, 18361 (2001).

    CAS  Article  Google Scholar 

  72. 72

    http://visibleearth.nasa.gov/; http://rapidfire.sci.gsfc.nasa.gov/firemaps/.

  73. 73

    http://www.usatoday.com/educate/college/healthscience/articles/20050925.htm

  74. 74

    http://www.lpi.usra.edu/expmoon/Apollo17/A17_Experiments_SMI.html

  75. 75

    A. Taylor, H. H. Schmitt, W. D. Carrier III, and M. Nakagawa, http://pdf.aiaa.org/preview/CDReadyMSEC05_1205/PV2005(2510.pdf

  76. 76

    http://science.nasa.gov/headlines/y2005/18mar_moonfirst.htm

  77. 77

    T. Watson, USA Today, 18 September 2005.

  78. 78

    I. D. Batsura, G. G. Kruglikov, and V. D. Arutiunov, Biull Eksp Biol. Med. 92, 376 (1981).

    Article  Google Scholar 

  79. 79

    A. Sapkota et al., Environ. Sci. Technol. 39, 24 (2005).

    CAS  Article  Google Scholar 

  80. 80

    http://maps.geog.umd.edu/

  81. 81

    J. A. Mott, P. Meyer, D. Mannino, S. C. Redd, E. M. Smith, C. Gotway-Crawford, and E. Chase, West. J. Med. 176 157 (2002).

    Article  Google Scholar 

  82. 82

    E. Yano, Y. Yokoyama, H. Higashi, S. Nishii, K. Maeda, and A. Koizumi, Arch. Environ. Health 45, 367 (1990).

    CAS  Article  Google Scholar 

  83. 83

    G. Blundell, W. Henderson, and E. W. Price, Ann. Trop. Med. Parasitol. 83, 381 (1989).

    CAS  Google Scholar 

  84. 84

    M. Corachan, Med. Clin. (Barc) 91, 97 (1988).

    CAS  Google Scholar 

  85. 85

    M. Corachan, J. M. Tura, E. Campo, M. Soley, and A. Traveria, Trop. Geogr Med. 40, 359 (1988).

    CAS  Google Scholar 

  86. 86

    M. Montella et al., Epidemiol. Prev. 21, 114 (1997).

    CAS  Google Scholar 

  87. 87

    L. C. Fuller, Curr. Opin. Infect. Dis. 18, 119 (2005).

    Article  Google Scholar 

  88. 88

    G. A. Thibodeau and K. T. Patton, Anatomy and Physiology, 5th ed. (Mosby, St. Louis, 2003).

    Google Scholar 

  89. 89

    National Aeronautics and Space Administration, Image ID: S73-15171, http://nix.larc.nasa.gov/ 90M. C. Malin et al., MOC2-314, http://photojournal.jpl.nasa.gov/; MOC2-1378, http://photojournal.jpl.nasa.gov/

  90. 91

    J. Li, M. Posfai, P. V. Hobs, and P. R. Buseck, J. Geophys. Res. 108, 8484 (2003).

    Article  CAS  Google Scholar 

  91. 92

    G. Davey, E. G. Hanna, A. Adeyemo, C. Rotimi, M. Newport, and K. Desta, Trans. R. Soc. Trop. Med. Hyg. 101, 91 (2007).

  92. 93

    http://visibleearth.nasa.gov/view_rec.php?vev1id=25928

  93. 94

    S. T. Ballard, J. C. Parker, and C. R. Hamm, Am. J. Respir. Cell Mol. Biol. 34, 500 (2006).

    CAS  Article  Google Scholar 

  94. 95

    Image ID: STS064-040-010, STS068-214-043, ISS005-E-19013, and ISS005-E-19024, http://eol.jsc.nasa.gov

  95. 96

    Louisa Howard, louisa.howard@dartmouth.edu; http://remf.dartmouth.edu/imagesindex.html

  96. 97

    A. Ahmad, S. Senapati, M. I. Khan, R. Kumar, and M. Sastry, J. Biomed. Nanotech. 1, 47 (2005), and references therein.

    CAS  Article  Google Scholar 

  97. 98

    P. Lunetta, A. Penttila, and G. Hallfors, Int. J. Legal Med. 111, 229 (1998).

    CAS  Article  Google Scholar 

  98. 99

    Ross Inman, Institute for Molecular Virology & Department of Biochemistry, University of Wisconsin-Madison, http://www.biochem.wisc.edu/inman/empics/virus.htm

  99. 100

    E. O. Kajander, Lett. Appl. Microbiol. 42, 549 (2006), and references therein.

    CAS  Google Scholar 

  100. 101

    H. Checkoway, N. J. Heyer, P. A. Demers, and N. E. Breslow, Br. J. Ind. Med. 50, 586 (1993).

    CAS  Google Scholar 

  101. 102

    B. D. Rawal and A. M. Pretorius, Med. Hypotheses 65, 1062 (2005).

    CAS  Article  Google Scholar 

  102. 103

    N. Ciftcioglu, R. S. Haddad, D. C. Golden, D. R. Morrison, and D. S. McKay, Kidney Int. 67, 483 (2005).

    CAS  Article  Google Scholar 

  103. 104

    H. M. Wood and D. A. Shoskes, World J. Urol. 24, 51 (2006).

    Article  Google Scholar 

  104. 105

    A. P. Sommer, N. Miyake, N. C. Wickramasinghe, J. V. Narlikar, and S. Al-Mufti, J. Proteome Res. 3, 12996 (2004).

    Google Scholar 

  105. 106

    F. Rogers, P. Arnott, B. Zielinska, J. Sagebiel, K. E. Kelly, D. Wagner, J. S. Lighty, and A. F. Sarofim, J. Air Waste Manage. Assoc. 55, 583 (2005).

    CAS  Google Scholar 

  106. 107

    W. S. Seames, A. Fernandez, and J. O. Wendt, Environ. Sci. Technol. 36, 2772 (2002).

    CAS  Article  Google Scholar 

  107. 108

    W. P. Linak, C. A. Miller, and J. O. Wendt, J. Air Waste Manage. Assoc. 50, 1532 (2000).

    CAS  Google Scholar 

  108. 109

    Health Assessment for Diesel Exhaust (U.S. Environmental Protection Agency, Washington, DC, 2002).

  109. 110

    D. Westerdahl, S. Fruin, T. Sax, P. M. Fine, and C. Sioutas, Atmos. Environ. 39, 3597 (2005).

    CAS  Article  Google Scholar 

  110. 111

    A. Evelyn, S. Mannick, and P. A. Sermon, Nano Lett. 3, 63 (2003).

    CAS  Article  Google Scholar 

  111. 112

    K. F. Soto, A. Carrasco, T. G. Powell, K. M. Garza, and L. E. Murr, J. Nanopart. Res. 7, 145 (2005) and references therein.

    CAS  Article  Google Scholar 

  112. 113

    A. Kocbach, Y. Li, K. E. Yttri, F. R. Cassee, P. E. Schwarze, and E. Namork, Part. Fibre Toxicol 3, 1 (2006).

    Article  CAS  Google Scholar 

  113. 114

    M. Singh, H. C. Phuleria, K. Bowers, and C. Sioutas, J. Expo Anal Environ. Epidemiol. 16, 3 (2006), and references therein.

    Article  Google Scholar 

  114. 115

    A. Penn, G. Murphy, S. Barker, W. Henk, and L. Penn, Environ. Health Perspect., 113, 956 (2005).

    CAS  Article  Google Scholar 

  115. 116

    J. Vermylen, A. Nemmar, B. Nemery, and F. Hoylaerts, J. Thromb. Haemost. 3, 1955 (2005) and references therein.

    CAS  Article  Google Scholar 

  116. 117

    G. Hoek, B. Brunekreef, S. Goldbohm, P. Fischer, and P. A. van den Brandt, Lancet 360, 1203 (2002).

    Article  Google Scholar 

  117. 118

    E. G. Knox, J. Epidemiol. Community Health 59, 755 (2005).

    CAS  Article  Google Scholar 

  118. 119

    C. Bigert, P. Gustavsson, J. Hallqvist, C. Hogstedt, M. Lewne, N. Plato, C. Reuterwall, and P. Scheele, Epidemiology 14, 333 (2003).

    Google Scholar 

  119. 120

    M. Riediker, R. B. Devlin, T. R. Griggs, M. C. Herbst, P. A. Bromberg, R. W. Williams, and W. E. Cascio, Part. Fibre Toxicol. 4, 2 (2004).

    Article  CAS  Google Scholar 

  120. 121

    E. Garshick, M. B. Schenker, A. Muñoz, T. Segal, T. J. Smith, S. Woskiw, S. K. Hammond, and F. E. Speizer, Am. J. Respir. Dis. 137, 820 (1988).

    CAS  Google Scholar 

  121. 122

    Environmental Protection Agency http://www.epa.gov/iaq/index.html;www.epa.gov/airtrends/pmreport03/pmunderstand(2405.pdf.

  122. 123

    A. Afshari, U. Matson, and L. E. Ekberg, Indoor Air 15, 141 (2005).

    CAS  Article  Google Scholar 

  123. 124

    S. W. See and R. Balasubramanian, Environ. Res. 102, 197 (2006).

    CAS  Article  Google Scholar 

  124. 125

    World Health Organization http://www.who.int/heli/risks/indoorair/indoorair/en/index.html

  125. 126

    P. J. Lioy, N. C. G. Freeman, and J. R. Millette, Environ. Health Perspect. 110, 969 (2002).

    CAS  Article  Google Scholar 

  126. 127

    Z. Ning, C. S. Cheung, J. Fu, M. A. Liu, and M. A. Schnell, Sci. Total Environ. 367, 822 (2006).

    CAS  Article  Google Scholar 

  127. 128

    L. Rushton, Rev. Environ. Health 19, 291, (2004) and references therein.

    CAS  Google Scholar 

  128. 129

    K. Husgafvel-Pursiainen, Mutat Res. 567, 427 (2004).

    CAS  Article  Google Scholar 

  129. 130

    X. L. Wang and J. Wang, World J. Surg. 29, 344 (2005).

    CAS  Article  Google Scholar 

  130. 131

    N. S. Godtfredsen, M. Osler, J. Vestbo, I. Andersen, and E. Prescott, J. Epidemiol. Community Health 57, 412 (2003).

    CAS  Article  Google Scholar 

  131. 132

    D. Stefani, D. Wardman, and T. Lambert, J. Air Waste Manage. Assoc. 55, 52 (2005).

    CAS  Google Scholar 

  132. 133

    see for example E. M. Fireman et al., Environ. Health Perspect. 112, 1564 (2004), and references therein.

    CAS  Article  Google Scholar 

  133. 134

    P. J. Lioy et al., Environ. Health Perspect. 110, 703 (2002).

    CAS  Article  Google Scholar 

  134. 135

    J. K. McGee et al., Environ. Health Perspect. 111, 972 (2003).

    CAS  Article  Google Scholar 

  135. 136

    Agera® Rx Medical Formula http://www.agerarx.co.uk/whatisagera.asp

  136. 137

    L. Xiao, H. Takada, K. Maeda, M. Haramoto, and N. Miwa, Biomed. Pharmacother 59, 351 (2005).

    CAS  Article  Google Scholar 

  137. 138

    http://www.foe.org/camps/comm/nanotech/

  138. 139

    G. Brumfiel, Nature (London) 440, 262 (2006).

    CAS  Article  Google Scholar 

  139. 140

    J. R. Gurr, A. S. S. Wang, C. H. Chen, and K. Y. Jan, Toxicology 213, 66 (2005), and references therein.

    CAS  Article  Google Scholar 

  140. 141

    N. Serpone, A. Salinaro, and A. Emeline, Proc. SPIE 4258 86 (2001).

    CAS  Article  Google Scholar 

  141. 142

    J. Lademann, H. Weigmann, C. Rickmeyer, H. Barthelmes, H. Schaefer, G. Mueller, and W. Sterry, Skin Pharmacol. Appl. Skin Physiol. 12, 247 (1999).

    CAS  Article  Google Scholar 

  142. 143

    Y. Kubota et al., Br. J. Cancer 70, 1107 (1994).

    CAS  Article  Google Scholar 

  143. 144

    R. Dunford, A. Salinaro, L. Cai, N. Serpone, S. Horikoshi, H. Hidaka, and J. Knowland, FEBS Lett. 418, 87 (1997).

    CAS  Article  Google Scholar 

  144. 145

    B. Rehn, F. Seiler, S. Rehn, J. Bruch, and M. Maier, Toxicol. Appl. Pharmacol. 189, 84 (2003).

    CAS  Article  Google Scholar 

  145. 146

    H. Shintani, S. Kurosu, A. Miki, F. Hayashi, and S. Kato, Biocontrol Sci 11, 17 (2006).

    Google Scholar 

  146. 147

    S. Takenaka, E. Karg, C. Roth, H. Schulz, A. Ziesenis, U. Heinzmann, P. Schramel, and J. Heyder, Environ. Health Perspect. 109, 547 (2001), and references therein.

    CAS  Google Scholar 

  147. 148

    A. M. Gatti, S. Montanari, E. Monari, A. Gambarelli, F. Capitani, and B. Parisini, J. Mater. Sci.: Mater. Med. 15, 469 (2004).

    CAS  Article  Google Scholar 

  148. 149

    A. M. Gatti, Biomaterials 25, 385 (2004).

    CAS  Article  Google Scholar 

  149. 150

    J. M. Antonini, A. B. Santamaria, N. T. Jenkins, E. Albini, and R. Lucchini, Neurotoxicology 27, 304 (2006).

    CAS  Article  Google Scholar 

  150. 151

    R. J. Aitken, K. S. Creely, and C. L. Tran, www.hse.gov.uk/research/ rrpdf/rr274.pdf

  151. 152

    K. Robbie, J. C. Sit, and M. J. Brett, J. Vac. Sci. Technol. B 16, 1115 (1998).

    CAS  Article  Google Scholar 

  152. 153

    K. Robbie, G. Beydaghyan, T. Brown, C. Dean, J. Adams, and C. Buzea, Rev. Sci. Instrum. 75, 1089 (2004).

    CAS  Article  Google Scholar 

  153. 154

    Nanoparticles Information Library, The National Institute for Occupational Safety and Health, http://www2a.cdc.gov/niosh-nil/index.asp

  154. 155

    K. Kaminska, M. Suzuki, K. Kimura, Y. Taga, and K. Robbie, J. Appl. Phys. 95, 3055 (2004).

    CAS  Article  Google Scholar 

  155. 156

    K. Kaminska and K. Robbie, Appl. Opt. 43, 1570 (2004).

    CAS  Article  Google Scholar 

  156. 157

    K. Robbie and M. J. Brett, J. Vac. Sci. Technol. A 15, 1460 (1997).

    CAS  Google Scholar 

  157. 158

    C. Buzea, K. Kaminska, G. Beydaghyan, T. Brown, C. Elliott, C. Dean, and K. Robbie, J. Vac. Sci. Technol. B 23, 2545 (2005).

    CAS  Article  Google Scholar 

  158. 159

    C. Buzea, G. Beydaghyan, C. Elliott, and K. Robbie, Nanotechnology 16, 1986 (2005).

    CAS  Article  Google Scholar 

  159. 160

    C. P.Shah, Public Health and preventive medicine in Canada (University of Toronto Press, Toronto, Canada).

  160. 161

    H. Wang, T. B. Huff, D. A. Zweifel, W. He, P. S. Low, A. Wei, and J. X. Cheng, Proc. Natl. Acad. Sci. U.S.A. 102, 15752 (2005).

    CAS  Article  Google Scholar 

  161. 162

    B. Nemery, Eur. Respir. J. 3, 202 (1990).

    CAS  Google Scholar 

  162. 163

    L. A. Maier, J. Thorac. Imaging 17, 273 (2002).

    Article  Google Scholar 

  163. 164

    C. Paris, O. Bertrand, and R. R. de Abreu, Rev. Prat 54, 1660 (2004).

    Google Scholar 

  164. 165

    M. P. Waalkes, Mutat Res. 533, 107 (2003).

    CAS  Article  Google Scholar 

  165. 166

    K. G. McGrath, Eur. J. Cancer Prev. 12, 479 (2003).

    CAS  Article  Google Scholar 

  166. 167

    O. Guillard, B. Fauconneau, D. Olichon, G. Dedieu, and R. Deloncle, Am. J. Med. 117, 956 (2004).

    Article  Google Scholar 

  167. 168

    M. Kawahara, J. Alzheimers Dis 8, 171 (2005).

    CAS  Google Scholar 

  168. 169

    A. C. Miu and O. Benga, J. Alzheimers Dis. 10, 179 (2006).

    CAS  Google Scholar 

  169. 170

    R. Deloncle, O. Guillard, F. Huguet, and F. Clanet, Biol. Trace Elem. Res. 47, 227 (1995).

    CAS  Article  Google Scholar 

  170. 171

    B. Weiss, Neurotoxicology 27, 362 (2006).

    CAS  Article  Google Scholar 

  171. 172

    T. Simonart, BMC Cancer 4, 1 (2004), and references therein.

    Article  Google Scholar 

  172. 173

    C. Quintana et al., J. Struct. Biol. 153, 42 (2006), and references therein.

    CAS  Article  Google Scholar 

  173. 174

    C. W. Noonan, J. C. Pfau, T. C. Larson, and M. R. Spence, Environ. Health Perspect. 114, 1243 (2006).

    CAS  Article  Google Scholar 

  174. 175

    P. J. A. Borm and L. Tran, Ann. Occup. Hyg. 46, 25 (2002).

    Article  Google Scholar 

  175. 176

    P. Gustavsson, A. Gustavsonn, and C. Hogstedt, Br. J. Ind. Med. 45, 777 (1988).

    CAS  Google Scholar 

  176. 177

    Wikipedia, http://en.wikipedia.org/wiki/Asbestos

  177. 178

    R. M. Gaafar and N. H. A. Eldin, Lung Cancer 49, S17 (2005).

  178. 179

    J. C. Pfau, J. J. Sentissi, G. Weller, and E. A. Putnam, Environ. Health Perspect. 113, 25 (2005).

    CAS  Article  Google Scholar 

  179. 180

    C. J. Johnston, J. N. Finkelstein, P. Mercer, N. Corson, R. Gelein, and G. Oberdorster, Toxicol. Appl. Pharmacol. 168, 208 (2000), and references therein.

    CAS  Article  Google Scholar 

  180. 181

    J. Ferin and G. Oberdorster, Acta Astronaut. 27, 257 (1992).

    CAS  Article  Google Scholar 

  181. 182

    T. H. Tuch, P. Brand, H. E. Wichmann, and J. Heyder, Atmos. Environ. 31, 4187 (1997).

    Article  Google Scholar 

  182. 183

    A. Chung, J. D. Herner, and M. J. Kleeman, Environ. Sci. Technol. 35, 2184 (2001).

    CAS  Article  Google Scholar 

  183. 184

    http://www.airqualityontario.com/

  184. 185

    Image ID: GL-2002-001716, http://www.gsfc.nasa.gov/

  185. 186

    Image ID: F09(0017, http://www-misr.jpl.nasa.gov/index.html

  186. 187

    D. W. Dockery et al., Environ. Health Perspect. 113, 670 (2005).

    CAS  Article  Google Scholar 

  187. 188

    M. Lippmann et al., Environ. Health Perspect. 111, 1074 (2003).

    CAS  Article  Google Scholar 

  188. 189

    A. Peters, H. E. Wichmann, T. Tuch, J. Heinrich, and J. Heyder, Am. J. Respir. Crit. Care Med. 155, 1376 (1997).

    CAS  Google Scholar 

  189. 190

    A. Peters, D. W. Dockery, J. E. Muller, and M. A. Mittleman, Circulation 103, 2810 (2001).

    CAS  Google Scholar 

  190. 191

    J. Schwartz and R. Morris, Am. J. Epidemiol. 142, 23 (1995).

    CAS  Google Scholar 

  191. 192

    C. A. Pope, R. T. Burnett, M. J. Thun, E. E. Calle, D. Krewski, K. Ito, and G. D. Thurston, JAMA, J. Am. Med. Assoc. 286, 1132 (2002).

    Article  Google Scholar 

  192. 193

    D. Bates and R. Sizto, Environ. Res. 47, 317 (1987).

    Article  Google Scholar 

  193. 194

    K. Iwai, S. Mizuno, Y. Miyasaka, and T. Mori, Environ. Res. 99, 106 (2005).

    CAS  Article  Google Scholar 

  194. 195

    D. E. Abey, N. Nishino, W. F. McDonnel, R. J. Burchette, S. F. Knutsen, W. L. Beeson, and J. X. Yang, Am. J. Respir. Crit. Care Med. 159, 373 (1999).

    Google Scholar 

  195. 196

    A. Nemmar et al., Circulation 105, 411 (2002), and references therein.

    CAS  Article  Google Scholar 

  196. 197

    S. M. Gilboa, P. Mendola, A. F. Olshan, P. H. Langlois, D. A. Savitz, D. Loomis, A. H. Herring, and D. E. Fixler, Am. J. Epidemiol. 162, 238 (2005).

    CAS  Article  Google Scholar 

  197. 198

    R. J. Sram, B. Binkova, J. Dejmek, and M. Bobak, Environ. Health Perspect. 113, 375 (2005).

    CAS  Article  Google Scholar 

  198. 199

    R. Kaiser, I. Romieu, S. Medina, J. Schwartz, M. Krzyzanowski, and N. Künzli, Environ. Health: A Global Access Science Source 3, 4 (2004), http://www.ehjournal.net/content/3/1/4.

    Article  Google Scholar 

  199. 200

    J. Schwartz and A. Marcus, Am. J. Epidemiol. 131, 185 (1990).

    CAS  Google Scholar 

  200. 201

    J. Chen, M. Tan, A. Nemmar, W. Song, M. Dong, G. Zhang, and Y. Li, Inhalation Toxicol. 222, 195 (2006).

    CAS  Google Scholar 

  201. 202

    J. S. Brown, K. L. Zeman, and W. D. Bennett, Am. J. Respir. Crit. Care Med. 166, 1240 (2002).

    Article  Google Scholar 

  202. 203

    P. Wiebert et al., Inhalation Toxicol. 18, 741 (2006).

    CAS  Article  Google Scholar 

  203. 204

    M. Ballestri et al., Gastroenterology 121, 1234 (2001).

    CAS  Article  Google Scholar 

  204. 205

    A. Peters et al., Part. Fibre Toxicol. 3, 13 (2006).

    Article  CAS  Google Scholar 

  205. 206

    I. Romieu, Int. J. Tuberc. Lung Dis. 9, 362 (2005).

    CAS  Google Scholar 

  206. 207

    A. Elder et al., Environ. Health Perspect. 114, 1172 (2006).

    CAS  Article  Google Scholar 

  207. 208

    M. Lippmann, Environ. Health Perspect. 88, 311 (1990).

    CAS  Article  Google Scholar 

  208. 209

    D. T. Wright, L. A. Cohn, H. Li, B. Fischer, C. M. Li, and K. B. Adler, Environ. Health Perspect. 102, 85 (1994).

    CAS  Google Scholar 

  209. 210

    D. Hopwood, E. M. Spiers, P. E. Ross, J. T. Anderson, J. B. McCullough, and F. E. Murray, Gut 37, 598 (1995).

    CAS  Article  Google Scholar 

  210. 211

    K. S. Saladin,, Anatomy & Physiology, 3rd ed. (McGraw Hill, New York, 2003).

    Google Scholar 

  211. 212

    M. Semmler, J. Seitz, P. Mayer, J. Heyder, G. Oberdörster, and W. G. Kreyling, Inhalation Toxicol. 16, 453 (2004).

    CAS  Article  Google Scholar 

  212. 213

    A. W. Ng, A. Bidani, and T. A. Heming, Lung 182, 297 (2004).

    Article  Google Scholar 

  213. 214

    A. Aderem and D. M. Underhill, Annu. Rev. Immunol. 17, 593 (1999).

    CAS  Article  Google Scholar 

  214. 215

    M. C. Garnet and P. Kallinteri, Occup. Med. 56 307 (2006).

    Article  Google Scholar 

  215. 216

    A. Palecanda and L. Kobzik, Methods 21, 241 (2000).

    CAS  Article  Google Scholar 

  216. 217

    L. Kobzik, J. Immunol. 155, 367 (1995).

    CAS  Google Scholar 

  217. 218

    K. I. Inoue, H. Takano, R. Yanagisawa, S. Hirano, T. Ichinose, A. Shimada, and T. Yoshikawa, Arch. Toxicol. 80, 275 (2006).

    CAS  Article  Google Scholar 

  218. 219

    J. B. Park, Exp. Mol. Med. 35, 325 (2003).

    CAS  Google Scholar 

  219. 220

    A. E. Porter, K. Muller, J. Skepper, P. Midgley, and M. Welland, Acta Biomater 2, 409 (2006).

    Article  Google Scholar 

  220. 221

    D. M. Brown, K. Donaldson, and V. Stone, Respir. Res 5, 29 (2004).

    CAS  Article  Google Scholar 

  221. 222

    G. Oberdörster, J. Ferin, and B. E. Lehnert, Environ. Health Perspect. 102, 173 (1994).

    Google Scholar 

  222. 223

    G. Oberdörster, J. Aerosol Med 1, 289 (1988).

    Article  Google Scholar 

  223. 224

    J. Muller et al., Toxicol. Appl. Pharmacol. 207, 221 (2005).

    CAS  Article  Google Scholar 

  224. 225

    G. Oberdorster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, W. Kreyling, and C. Cox, Inhalation Toxicol. 16, 437 (2004).

    CAS  Article  Google Scholar 

  225. 226

    J. Liu, H. L. Wong, J. Moselhy, B. Bowen, X. Y. Wu, and M. R. Johnston, Lung Cancer 51, 377 (2006), and references therein.

    Article  Google Scholar 

  226. 227

    C. Dasenbrock, L. Peters, O. Creutzenberg, and U. Heinrich, Toxicol. Lett. 88, 15 (1996).

    CAS  Article  Google Scholar 

  227. 228

    K. E. Driscoll, J. M. Carter, B. W. Howard, D. G. Hassenbein, W. Pepelko, R. B. Baggs, and G. Oberdoster, Toxicol. Appl. Pharmacol. 136, 327 (1996).

    Article  Google Scholar 

  228. 229

    K. J. Nikula, M. B. Snipes, E. B. barr, W. C. Griffith, R. F. Henderson, and J. L. Mauderly, Fundam. Appl. Toxicol. 25, 80 (1995).

    CAS  Article  Google Scholar 

  229. 230

    M. Lucarelli, A. M. Gatti, G. Savarino, P. Quatronni, L. Martinelli, E. Monari, and D. Boraschi, Eur. Cytokine Netw. 15, 339 (2004).

    CAS  Google Scholar 

  230. 231

    L. C. Renwick, K. Donaldson, and A. Clouter, Toxicol. Appl. Pharmacol. 172, 119 (2001).

    CAS  Article  Google Scholar 

  231. 232

    P. M. H. Hoet and B. Nemery, Toxicol. Appl. Pharmacol. 176, 203 (2001).

    CAS  Article  Google Scholar 

  232. 233

    S. C. Wesselkamper, L. C. Chen, and T. Gordon, Respir. Res. 6, 73 (2005).

    Article  CAS  Google Scholar 

  233. 234

    N. Sood, W. D. Bennett, K. Zeman, J. Brown, C. Foy, R. C. Boucher, and M. R. Knowles, Am. J. Respir. Crit. Care Med. 167, 158 (2003).

    Article  Google Scholar 

  234. 235

    T. Xia et al., Nano Lett. 6, 1794 (2006).

    CAS  Article  Google Scholar 

  235. 236

    M. Geiser et al., Environ. Health Perspect. 113, 1555 (2005).

    Article  Google Scholar 

  236. 237

    E. Garcia-Garcia et al., Int. J. Pharm. 298, 310 (2005).

    CAS  Article  Google Scholar 

  237. 238

    N. Li et al., Environ. Health Perspect. 111, 455 (2003).

    Google Scholar 

  238. 239

    V. Stone, J. Shaw, D. M. Brown, W. MacNee, S. P. Faux, and K. Donaldson, Toxicol. In Vitro 12, 649 (1998).

    CAS  Article  Google Scholar 

  239. 240

    M. Singal and J. N. Finkelstein, Exp. Lung Res. 31, 581 (2005).

    CAS  Article  Google Scholar 

  240. 241

    W. G. Kreyling, M. Semmler, F. Erbe, P. Mayer, S. Takenata, G. Oberdörster, and A. Ziesenis, J. Toxicol. Environ. Health 65, 1513 (2002).

    CAS  Article  Google Scholar 

  241. 242

    J. F. Kukowska-Latallo et al., Cancer Res. 65, 5317 (2005).

    CAS  Article  Google Scholar 

  242. 243

    T. Kato, T. Yashiro, Y. Murata, D. C. Herbert, K. Oshikawa, M. Bando, S. Ohno, and Y. Sugiyama, Cell Tissue Res. 311, 47 (2003).

    Article  Google Scholar 

  243. 244

    P. Juvin, T. Fournier, S. Boland, P. Soler, F. Marano, J. M. Desmonts, and M. Aubier, Arch. Environ. Health 57, 53 (2002).

    CAS  Article  Google Scholar 

  244. 245

    B. M. Rothen-Rutishauser, S. Schurch, B. Haenni, N. Kapp, and P. Gehr, Environ. Sci. Technol. 40, 4353 (2006).

    CAS  Article  Google Scholar 

  245. 246

    A. Nemmar, M. F. Hoylaerts, P. H. M. Hoet D. Dinsdale, T. Smith, H. Xu, J. Vermylen, and B. Nemery, Am. J. Respir. Crit. Care Med. 166, 998 (2002).

    Article  Google Scholar 

  246. 247

    G. Oberdörster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, and A. Lunts, J. Toxicol. Environ. Health 65, 1531 (2002).

    Article  CAS  Google Scholar 

  247. 248

    D. M. Brown, K. Donaldson, P. J. Borm, R. P. Schins, M. Dehnhardt, P. Gilmour, L. A. Jimenez, and V. Stone, J. Physiol. Lung Cell. Mol. Physiol 286, L344 (2004).

    CAS  Article  Google Scholar 

  248. 249

    H. Long, T. Shi, P. J. Borm, J. Määttä, K. Husgafvel-Pursiainen, K. Savolainen, and F. Krombach, Part. Fibre Toxicol 1, 3 (2004).

    Article  CAS  Google Scholar 

  249. 250

    M. R. Wilson, J. H. Lightbody, K. Donaldson, J. Sales, and V. Stone, Toxicol. Appl. Pharmacol. 184, 172 (2002).

    CAS  Article  Google Scholar 

  250. 251

    Y. Lim, S. H. Kim, Y. J. Cho, K. A. Kim, M. W. Oh, and K. H. Lee, Ind. Health 35, 380 (1997).

    CAS  Article  Google Scholar 

  251. 252

    M. C. E. Lomer, R. P. H. Thompson, and J. J. Powell, Proc. Nutr. Soc. 61, 123 (2002), and references therein.

    Article  Google Scholar 

  252. 253

    G. Liu, P. Mena, P. R. L. Harris, R. K. Rolston, G. Perry, and M. A. Smith, Neurosci. Lett. 406, 189 (2006).

    CAS  Article  Google Scholar 

  253. 254

    P. Bourrinet, H. H. Bengele, B. Bennemain, A. Dencausse, J. M. Idee, P. M. Jacobs, and J. M. Lewis, Invest. Radiol. 41, 313 (2006).

    CAS  Article  Google Scholar 

  254. 255

    O. Rabin, J. M. Perez, J. Grimm, G. Wojtkiewiccz, and R. Weissleder, Nat. Mater. 5, 118 (2006).

    CAS  Article  Google Scholar 

  255. 256

    S. M. Chung, J. Neuroophthalmol. 22, 35 (2002).

    Article  Google Scholar 

  256. 257

    P. R. Lockman, J. M. Koziara, R. J. Mumper, and D. D. Allen, J. Drug Target. 12, 635 (2004).

    CAS  Article  Google Scholar 

  257. 258

    A. Campbell et al., Neurotoxicology 26, 133 (2005).

    CAS  Article  Google Scholar 

  258. 259

    L. Calderon-Garciduenas et al., Toxicol. Pathol. 31, 524 (2003).

    CAS  Article  Google Scholar 

  259. 260

    E. Oberdörster, Environ. Health Perspect. 112, 1058 (2004).

    Article  CAS  Google Scholar 

  260. 261

    C. Mount and C. Downton, Nat. Med. 12, 780 (2006).

    CAS  Article  Google Scholar 

  261. 262

    T. T. W. Shwe S. Yamamoto, M. Kakeyama, T. Kobayashi, and H. Fujimaki, Toxicol. Appl. Pharmacol. 209, 51 (2005).

    Article  CAS  Google Scholar 

  262. 263

    N. L. Mills et al., Am. J. Respir. Crit. Care Med. 173, 426 (2005).

    Article  Google Scholar 

  263. 264

    P. Wiebert et al., Eur. Respir. J., 28, 286 (006).

    Article  Google Scholar 

  264. 265

    A. M. Gatti, S. Montanari, A. Gambarelli, F. Capitani, and R. Salvatori, J. Mater. Sci.: Mater. Med. 16, 1213 (2005).

    CAS  Article  Google Scholar 

  265. 266

    A. Nemmar, B. Nemery, M. F. Hoylaerts, and J. Vaermylen, Pathophysiol. Haemost. Thromb 32, 349 (2002).

    CAS  Article  Google Scholar 

  266. 267

    H. Schulz et al., J. Aerosol Med. 18, 1 (2005).

    CAS  Article  Google Scholar 

  267. 268

    A. Nemmar, H. Vanbilloen, M. F. Hoylaerts, P. H. Hoet, A. Verbruggen, and B. Nemery, Am. J. Respir. Crit. Care Med. 164, 1665 (2001).

    CAS  Google Scholar 

  268. 269

    A. J. Schwab and K. S. Pang, Environ. Health Perspect. 108, 861 (2000).

    CAS  Google Scholar 

  269. 269

    270A. M. Gatti and F. Rivasi, Biomaterials 23, 2381 (2002), and references therein.

    CAS  Article  Google Scholar 

  270. 271

    J. R. Cooper, G. N. Stradling, H. Smith, and S. E. Breadmore, Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 36, 453 (1979).

    CAS  Article  Google Scholar 

  271. 272

    M. C. E. Lomer, C. Hutchinson, S. Volkert, S. M. Greenfield, A. Catterall, R. P. H. Thompson, and J. J. Powell, Br. J. Nutr. 92, 947 (2004).

    CAS  Article  Google Scholar 

  272. 273

    P. Jani, G. W. Halbert, J. Langridge, and A. T. Florence, J. Pharm. Pharmacol. 42, 821 (1990).

    CAS  Article  Google Scholar 

  273. 274C.

    S. Rae et al., Virology, 343, 224 (2005).

  274. 275

    J. J. Powell, C. C. Ainley, R. S. Harvey, I. M. Manson, M. D. Kendall, E. A. Sankey, A. P. Dhillon, and R. P. Thompson, Gut 38, 390 (1996).

    CAS  Article  Google Scholar 

  275. 276

    R. Toll, U. Jacobi, H. Richter, J. Lademann, H. Schaefer, and U. Blume-Peytavi, J. Invest. Dermatol. 123, 168 (2004).

    CAS  Article  Google Scholar 

  276. 277

    S. S. Tinkle, J. M. Antonini, B. A. Rich, J. R. Roberts, R. Salmen, K. DePree, and E. J. Adkins, Environ. Health Perspect. 111, 1202 (2003).

    CAS  Article  Google Scholar 

  277. 278

    N. A. Monteiro-Riviere, R. J. Nemanich, A. O. Inman, Y. Y. Wang, and J. E. Riviere, Toxicol. Lett. 155, 377 (2005).

    CAS  Article  Google Scholar 

  278. 279

    J. S. Tsuji, A. D. Maynard, P. C. Howard, J. T. James, C. W. Lam, D. B. Warheit, and A. B. Santamaria, Toxicol. Sci. 89, 42 (2006), and references therein.

    CAS  Article  Google Scholar 

  279. 280

    G. J. Nohynek, J. Lademann, C. Ribaud, and M. S. Roberts, Crit. Rev. Toxicol. 37, 251 (2007), and references therein.

    CAS  Article  Google Scholar 

  280. 281

    G. Oberdörster, J. Ferin, R. Gelein, S. C. Soderholm, and J. Finkelstein, Environ. Health Perspect. 97, 193 (1992).

    Google Scholar 

  281. 282

    K. Peters, R. E. Unger, C. J. Kirkpatrick, A. M. Gatti, and E. Monari, J. Mater. Sci.: Mater. Med. 15, 321 (2004).

    CAS  Article  Google Scholar 

  282. 283

    V. K. Poon and A. Burd, Burns 30, 140 (2004), and references therein.

    Article  Google Scholar 

  283. 284

    K. Dunn and V. Edwards-Jones, Burns 30, S1 (2004).

    Article  Google Scholar 

  284. 285

    L. Araujo, R. Lobenberg, and J. Kreuter, J. Drug Target. 6, 373 (1999).

    CAS  Article  Google Scholar 

  285. 286

    V. Labhasetwar, C. Song, W. Humphrey, R. nShebuski, and R. J. Levy, J. Pharm. Sci. 87, 1229 (1998).

    CAS  Article  Google Scholar 

  286. 287

    L. Reijnders, J. Cleaner Prod. 14, 124 (2006), and references therein.

    Article  Google Scholar 

  287. 288

    T. I. Visuri, E. Pukkala, P. Pulkkinen, and P. Paavolainen, Proc. Inst. Mech. Eng., Part H: J. Eng. Med. 220, 399 (2006).

    CAS  Article  Google Scholar 

  288. 289

    N. Hallab, K. Merritt, and J. J. Jacobs, J. Bone Jt. Surg., Am. Vol. 83, 428 (2001).

    Article  Google Scholar 

  289. 290

    I. Milosev, R. Trebse, S. Kovac, A. Cor, and V. Pisot, J. Bone Jt. Surg., Am. Vol. 88, 1173 (2006).

    Article  Google Scholar 

  290. 291

    M. L. Wang, R. Tuli, P. A. Manner, P. F. Sharkey, D. J. Hall, and R. S. Tuan, J. Orthop. Res. 21, 697 (2003).

    CAS  Article  Google Scholar 

  291. 292

    Y. Li, P. Leung, L. Yao, Q. W. Song, and E. Newton, J. Hosp. Infect. 62, 58 (2006).

    CAS  Article  Google Scholar 

  292. 293

    R. Brayner, R. Ferrari-Iliou, N. Brivois, S. Djediat, M. F. Benedetti, and F. Fievet, Nano Lett. 6, 866 (2006).

    CAS  Article  Google Scholar 

  293. 294

    C. N. Lok et al., J. Proteome Res. 5, 916 (2006).

    CAS  Article  Google Scholar 

  294. 295

    J. L. Elechiguerra, J. L. Burt, J. R. Morones, A. Camacho-Bragado, X. Gao, H. H. Lara, and M. J. Yacaman, J. Nanobiotechnol 3, 6 (2005).

    Article  Google Scholar 

  295. 296

    T. Stoeger et al., Environ. Health Perspect. 114, 328 (2006).

    Article  Google Scholar 

  296. 297

    J. Ferin, G. Oberdörster, and D. P. Penney, Am. J. Respir. Cell Mol. Biol. 6, 535 (1992).

    CAS  Google Scholar 

  297. 298

    I. Balashazy, W. Hofmann, and T. Heistracher, J. Appl. Physiol. 94, 1719 (2003).

    Google Scholar 

  298. 299

    D. B. Warheit, T. R. Webb, C. M. Sayes, V. L. Colvin, and K. L. Reed, Toxicol. Sci. 91, 227 (2006).

    CAS  Article  Google Scholar 

  299. 300

    A. Churg, B. Stevend, and J. L. Wright, Am. J. Physiol. 274, L81 (1998).

    CAS  Google Scholar 

  300. 301

    H. Zhang, B. Gilbert, F. Huang, and J. F. Banfield, Nature (London) 424, 1025 (2003).

    CAS  Article  Google Scholar 

  301. 301

    302A. A. Shvedova et al., Am. J. Physiol. Cell Mol. Physiol. 289, L698 (2005).

    CAS  Article  Google Scholar 

  302. 303

    D. B. Warheit, B. R. Laurence, K. L. Reed, D. H. Roach, G. A. M. Reynolds, and T. R. Web, Toxicol. Sci. 77, 117 (2004).

    CAS  Article  Google Scholar 

  303. 304

    C. W. Lam, J. T. James, R. McCluskey, and R. L. Hunter, Toxicol. Sci. 77, 126 (2004).

    CAS  Article  Google Scholar 

  304. 305

    A. D. Maynard, P. A. Baron, M. Foley, A. A. Shvedova, E. R. Kisin, and V. Castranova, J. Toxicol. Environ. Health 67, 87 (2004).

    CAS  Article  Google Scholar 

  305. 306

    K. Donaldson and C. L. Tran, Mutat Res. 553, 5 (2004).

    CAS  Article  Google Scholar 

  306. 307

    P. Cherukuri, S. M. Bachilo, S. H. Litovsky, and R. B. Weisman, J. Am. Chem. Soc. 126, 15638 (2004).

    CAS  Article  Google Scholar 

  307. 308

    D. Cui, F. Tian, C. S. Ozkan, M. Wang, and H. Gao, Toxicol. Lett. 155, 73 (2005).

    CAS  Article  Google Scholar 

  308. 309

    G. Jia, H. Wang, L. Yan, X. Wang, R. Pei, T. Yan, Y. Zhao, and X. Guo, Environ. Sci. Technol. 39, 1378 (2005).

    CAS  Article  Google Scholar 

  309. 310

    H. Dai, Surf. Sci. 500, 218 (2002).

    CAS  Article  Google Scholar 

  310. 311

    M. Bottini, S. Bruckner, K. Nika, N. Bottini, S. Bellucci, A. Magrini, A. Bergamaschi, and T. Mustelin, Toxicol. Lett., 160, 121 (2006) and references therein.

    CAS  Article  Google Scholar 

  311. 312

    H. Yin, H. P. Too, and G. M. Chow, Biomaterials 26, 5818 (2005).

    CAS  Article  Google Scholar 

  312. 313

    A. K. Gupta and M. Gupta, Biomaterials 26, 1565 (2005).

    CAS  Article  Google Scholar 

  313. 314

    C. M. Sayes et al., Nano Lett. 4, 1881 (2004).

    CAS  Article  Google Scholar 

  314. 315

    L. Braydich-Stolle, S. Hussain, J. Schlager, and M. C. Hofmann, Toxicol. Sci. 88, 412 (2005).

    CAS  Article  Google Scholar 

  315. 316

    S. M. Hussain, K. L. Hess, J. M. Gearhart, K. T. Geiss, and J. J. Schlager, Toxicol. In Vitro 19, 975 (2005). 317www.nano.gov.

    CAS  Article  Google Scholar 

  316. 318

    M. C. Roco, J. Nanopart. Res. 7, 129 (2005).

    Article  Google Scholar 

  317. 319

    S. E. Thompson and S. Parthasarathy, Mater. Today 9, 20 (2006).

    CAS  Article  Google Scholar 

  318. 320

    M. Jacoby, Chem. Eng. News 80, 38 (2002).

    Article  Google Scholar 

  319. 321

    C. Buzea and K. Robbie, Semicond. Sci. Technol. 18, R1 (2005).

    CAS  Google Scholar 

  320. 322

    J. D. Carey, Philos. Trans. R. Soc. London, Ser. A 361, 2891 (2003).

    CAS  Article  Google Scholar 

  321. 323

    H. K. Liu, G. X. Wang, Z. Guo, J. Wang, and K. Konstantinov, J. Nanosci. Nanotechnol. 6, 1 (2006). 324http://www.immnet. com/articles?article(1750.

    Google Scholar 

  322. 325

    J. H. Hafner, C. L. Cheung, A. T. Woolley, and C. M. Lieber, Prog. Biophys. Mol. Biol. 77, 73 (2001).

    CAS  Article  Google Scholar 

  323. 326

    R. G. Ellis-Behnke, Y. X. Liang, S. W. You, D. K. Tay, S. Zhang, K. F. So, and G. E. Schneider, Proc. Natl. Acad. Sci. U.S.A. 103, 5054 (2006).

    CAS  Article  Google Scholar 

  324. 327

    O. B. Koper, J. S. Klabunde, G. L. Marchin, K. J. Klabunde, P. Stoimenov, and L. Bohra, Curr. Microbiol. 44, 49 (2002).

    CAS  Article  Google Scholar 

  325. 328

    K. B. Jirage, J. C. Hulteen, and C. R. Martin, Science 278, 655 (1997).

    CAS  Article  Google Scholar 

  326. 329

    C. R. Martin and P. Kohli, Nat. Rev. Drug Discovery 2, 29 (2003).

    CAS  Article  Google Scholar 

  327. 327

    330K. E. Uhrich, S. M. Cannizzaro, R. S. Langer, and K. M. Shakeshelf, Chem. Rev. (Washington, D.C.) 99, 3181 (1999).

    CAS  Google Scholar 

  328. 331

    L. Maïté, N. Carlesso, C. H. Tung, X. W. Tang, D. Cory, D. T. Scadden, and R. Weissleder, Nat. Biotechnol. 18, 410 (2000).

    Article  CAS  Google Scholar 

  329. 332

    C. Kneuer, M. Sameti, U. Bakowsky, T. Schiestel, H. Schirra, H. Schmidt, and C. M. Lehr, Bioconjugate Chem. 11, 926 (2000).

    CAS  Article  Google Scholar 

  330. 333

    M. G. Harisinghani, J. Barentsz, P. F. Hahn, W. M. Deserno, S. Tabatabaei, C. H. van de Kaa, J. de la Rosette, and R. Weissleder, N. Engl. J. Med. 348, 2491 (2003).

    Article  Google Scholar 

  331. 334

    M. Matsusaki, K. Larsson, T. Akagi, M. Lindstedt, M. Akashi, and C. A. K. Borrebaeck, Nano Lett. 5, 2168 (2005).

    CAS  Article  Google Scholar 

  332. 335

    N. L. Rosi and C. A. Mirkin, Chem. Rev. (Washington, D.C.) 105, 1547 (2005).

    CAS  Google Scholar 

  333. 336

    E. M. Renehan, F. K. Enneking, M. Varshney, R. Partch, D. M. Dennis, and T. E. Morey, Reg. Anesth. Pain Med. 30, 380 (2005).

    CAS  Google Scholar 

  334. 337

    G. Weinberg, R. Ripper, D. L. Feinstein, and W. Hoffman, Reg. Anesth. Pain Med. 28, 198 (2003).

    CAS  Google Scholar 

  335. 338

    J. Hogan, http://www.newscientist.com/.

  336. 339

    F. He and D. Y. Zhao, Environ. Sci. Technol. 39, 3314 (2005).

    CAS  Article  Google Scholar 

  337. 340

    http://www.nanophase. com/applications/textile_fibers. asp.

  338. 341

    L. W. Hrubesh and J. F. Poco, J. Non-Cryst. Solids 188, 46 (1995).

    CAS  Article  Google Scholar 

  339. 343

    B. Borup and W. Leuchtenberger, Mater. World 10, 20 (2002).

    Google Scholar 

  340. 344

    J. J. Stiglich, C. C. Yu, and T. S. Sudarshan, Proceedings of the Third International Confernece on Tungsten Refractory Metals, edited by Bose, Animesh, and Dowding(RJ Metal Powder Industries Federation, Princeton, NJ, 1996), pp. 229–236.

    Google Scholar 

  341. 345

    N. Fleischer, M. Genut, L. Rapoport, and R. Tenne, New Nanotechnology Solid Lubricants for Superior Dry Lubrication (European Space Agency, Noordwijk, Netherlands, 2003), pp. 65–66.

    Google Scholar 

  342. 346

    http://antwrp.gsfc.nasa.gov/apod/ap010813.html.

  343. 347

    Kevin Robbie (unpublished).

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Buzea, C., Pacheco, I.I. & Robbie, K. Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases 2, MR17–MR71 (2007). https://doi.org/10.1116/1.2815690

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