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Journal for Biophysical Chemistry

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  • Open Access

Micropatterned model biological membranes composed of polymerized and fluid lipid bilayers

  • 1

  • Received: 18 April 2008
  • Accepted: 6 June 2008


Micropatterned phospholipid bilayers on solid substrates offer an attractive platform for various applications, such as high-throughput drug screening. The authors have developed a photopolymerization-based methodology for generating micropatterned bilayers composed of polymerized and fluid lipid bilayers. Lithographic photopolymerization of a diacetylene-containing phospholipid (DiynePC) allowed facile fabrication of compartmentalized arrays of fluid lipid membranes. Herein, the authors report on the present state of research and discuss on the prospective application of the model membranes.