Skip to main content

Advertisement

Journal for Biophysical Chemistry

Biointerphases Cover Image

Micropatterned model biological membranes composed of polymerized and fluid lipid bilayers

Article metrics

  • 388 Accesses

Abstract

Micropatterned phospholipid bilayers on solid substrates offer an attractive platform for various applications, such as high-throughput drug screening. The authors have developed a photopolymerization-based methodology for generating micropatterned bilayers composed of polymerized and fluid lipid bilayers. Lithographic photopolymerization of a diacetylene-containing phospholipid (DiynePC) allowed facile fabrication of compartmentalized arrays of fluid lipid membranes. Herein, the authors report on the present state of research and discuss on the prospective application of the model membranes.

References

  1. 1

    E. Sackmann, Science 271, 43 (1996).

  2. 2

    M. Tanaka and E. Sackmann, Nature (London) 437, 656 (2005).

  3. 3

    H. Schönherr, G. H. Degenhart, B. Dordi, C. L. Feng, D. I. Rozkiewicz, A. Shovsky, and G. J. Vancso, Adv. Polym. Sci. 200, 169 (2006).

  4. 4

    J. T. Groves, N. Ulman, and S. G. Boxer, Science 275, 651 (1997).

  5. 5

    J. T. Groves and S. G. Boxer, Acc. Chem. Res. 35, 149 (2002).

  6. 6

    Y. Fang, A. G. Frutos, and J. Lahiri, J. Am. Chem. Soc. 124, 2394 (2002).

  7. 7

    A. Plant, Langmuir 15, 5128 (1999).

  8. 8

    J. Spinke, J. Yang, H. Wolf, M. Liley, H. Ringsdorf, and W. Knoll, Biophys. J. 63, 1667 (1992).

  9. 9

    S. M. Schiller, R. Naumann, K. Lovejoy, H. Kunz, and W. Knoll, Angew. Chem., Int. Ed. 42, 208 (2003).

  10. 10

    V. Atanasov, N. Knorr, R. S. Duran, S. Ingebrandt, A. Offenhäusser, W. Knoll, and I. Köper, Biophys. J. 89, 1780 (2005).

  11. 11

    H. Ringsdorf, B. Schlarb, and J. Venzmer, Angew. Chem., Int. Ed. Engl. 27, 113 (1988).

  12. 12

    A. Mueller and D. F. O’Brien, Chem. Rev. (Washington, D.C.) 102, 727 (2002).

  13. 13

    E. E. Ross, B. Bondurant, T. Spratt, J. C. Conboy, D. F. O’Brien, and S. S. Saavedra, Langmuir 17, 2305 (2001).

  14. 14

    K. Morigaki, T. Baumgart, A. Offenhäusser, and W. Knoll, Angew. Chem., Int. Ed. 40, 172 (2001).

  15. 15

    K. Morigaki, T. Baumgart, U. Jonas, A. Offenhäusser, and W. Knoll, Langmuir 18, 4082 (2002).

  16. 16

    K. Morigaki, H. Schönherr, C. W. Frank, and W. Knoll, Langmuir 19, 6994 (2003).

  17. 17

    K. Morigaki, K. Kiyosue, and T. Taguchi, Langmuir 20, 7729 (2004).

  18. 18

    J. T. Groves, S. G. Boxer, and H. M. McConnell, Proc. Natl. Acad. Sci. U.S.A. 94, 13390 (1997).

  19. 19

    G. Wiegand, T. Jaworek, G. Wegner, and E. Sackmann, Langmuir 13, 3563 (1997).

  20. 20

    S. Heyse, O. P. Ernst, Z. Dienes, K. P. Hofmann, and H. Vogel, Biochemistry 37, 507 (1998).

  21. 21

    A. T. A. Jenkins, N. Boden, R. J. Bushby, S. D. Evans, P. F. Knowles, R. E. Miles, S. D. Ogier, H. Schönherr, and G. J. Vancso, J. Am. Chem. Soc. 121, 5274 (1999).

  22. 22

    P. S. Cremer and T. Yang, J. Am. Chem. Soc. 121, 8130 (1999).

  23. 23

    J. S. Hovis and S. G. Boxer, Langmuir 16, 894 (2000).

  24. 24

    L. Kam and S. G. Boxer, J. Am. Chem. Soc. 122, 12901 (2000).

  25. 25

    S. Künneke and A. Janshoff, Angew. Chem., Int. Ed. 41, 314 (2002).

  26. 26

    T. Okazaki, K. Morigaki, and T. Taguchi, Biophys. J. 91, 1757 (2006).

  27. 27

    A. A. Brian and H. M. McConnell, Proc. Natl. Acad. Sci. U.S.A. 81, 6159 (1984).

  28. 28

    T. M. Bayerl and M. Bloom, Biophys. J. 58, 357 (1990).

  29. 29

    B. W. Koenig, S. Krueger, W. J. Orts, C. F. Majkrzak, N. F. Berk, J. V. Silverton, and K. Gawrisch, Langmuir 12, 1343 (1996).

  30. 30

    C. A. Keller and B. Kasemo, Biophys. J. 75, 1397 (1998).

  31. 31

    I. Reviakine and A. Brisson, Langmuir 16, 1806 (2000).

  32. 32

    R. P. Richter, R. Berat, and A. R. Brisson, Langmuir 22, 3497 (2006).

  33. 33

    K. Morigaki, H. Schönherr, and T. Okazaki, Langmuir 23, 12254 (2007).

  34. 34

    N. Yamaguchi and M. Kasai, Biochem. J. 335, 541 (1998).

  35. 35

    P. Martínez-Landeira, J. L. López-Fontán, J. M. Ruso, G. Prieto, and F. Sarmiento, Colloids Surf., A 216, 91 (2003).

  36. 36

    K. Tawa and K. Morigaki, Biophys. J. 89, 2750 (2005).

  37. 37

    K. Morigaki and K. Tawa, Biophys. J. 91, 1380 (2006).

  38. 38

    P. Anzenbacher and E. Anzenbacherova, Cell. Mol. Life Sci. 58, 737 (2001).

  39. 39

    K. R. Korzekwa and J. P. Jones, Pharmacogenetics 3, 1 (1993).

  40. 40

    Y. Ueda, K. Morigaki, Y. Tatsu, and N. Yumoto, Biochem. Biophys. Res. Commun. 355, 926 (2007).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article