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Biointerphases

Journal for Biophysical Chemistry

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Stimuli-responsive command polymer surface for generation of protein gradients

Biointerphases volume 4, pages FA45–FA49 (2009)Cite this article

Abstract

Mixed polyelectrolyte brushes with a composition gradient were used as a platform for fabrication of stimuli-responsive command surfaces to control the generation of concentration gradients of adsorbed protein molecules. Switching between homogeneously adsorbed protein layers and adsorbed layers with protein concentration gradients was achieved by changing the pH of protein aqueous solutions. Protein adsorption and the direction of the adsorption gradient were tuned and also turned off and on or reversed by tuning the proton concentration in the pH range 4.0–8.6.

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Authors and Affiliations

  1. Max-Planck-Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany

    Leonid Ionov

  2. Leibniz Institute of Polymer Research Dresden e.V, Hohe Str. 6, 01069, Dresden, Germany

    Nikolay Houbenov & Manfred Stamm

  3. Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, 19104-4495, Philadelphia, Pennsylvania, Germany

    Alexander Sidorenko

  4. Department of Chemistry and Biomolecular Science, NanoBio Laboratory (NABLAB), Clarkson University, 13699-5810, Potsdam, New York

    Sergiy Minko

Authors
  1. Leonid Ionov
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  2. Nikolay Houbenov
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  3. Alexander Sidorenko
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  4. Manfred Stamm
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  5. Sergiy Minko
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Ionov, L., Houbenov, N., Sidorenko, A. et al. Stimuli-responsive command polymer surface for generation of protein gradients. Biointerphases 4, FA45–FA49 (2009). https://doi.org/10.1116/1.3119722

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  • DOI: https://doi.org/10.1116/1.3119722