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Biointerphases

Journal for Biophysical Chemistry

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Versatile synthesis and micropatterning of nonfouling polymer brushes on the wafer scale

Biointerphases volume 4, pages FA50–FA57 (2009)Cite this article

Abstract

In this article, the authors describe new approaches to synthesize and pattern surfaces with poly[oligo(ethylene glycol) methyl methacrylate] (POEGMA) polymer brushes synthesized by surface-initiated atom transfer radical polymerization. These patterned coatings confer “nonfouling” properties protein and cell resistance—to the surface in a biological milieu. The versatile routes for the synthesis of POEGMA demonstrated here offer clear advantages over other techniques previously used in terms of their simplicity, reliability, and ability to pattern large-area substrates. They also demonstrate that POEGMA polymer brushes can be patterned directly by photolithography, plasma ashing, and reactive ion etching to create patterns at the micro- and nanoscale over large areas with high throughput and repeatability, while preserving the protein and cell resistance of the POEGMA brush.

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Author information

Author notes

  1. Andres Garcia

    Present address: Liquidia Technologies, Inc., 27709, Research Triangle Park, NC

  2. Matthew S. Johannes

    Present address: Applied Physics Laboratory, 20723, Laurel, MD

  3. Robert L. Clark

    Present address: School of Engineering and Applied Sciences, University of Rochester, 14627, Rochester, NY

Authors and Affiliations

  1. Department of Biomedical Engineering, Duke University, Box 90281, 27708, Durham, North Carolina

    Angus Hucknall, Andrew J. Simnick, Ryan T. Hill & Ashutosh Chilkoti

  2. Center for Biologically Inspired Materials and Material Systems, Duke University, 27708, Durham, North Carolina

    Angus Hucknall, Andrew J. Simnick, Ryan T. Hill, Ashutosh Chilkoti, Andres Garcia, Matthew S. Johannes, Robert L. Clark & Stefan Zauscher

  3. Department of Mechanical Engineering and Materials Science, Duke University, Box 9030, 27708, Durham, North Carolina

    Andres Garcia, Matthew S. Johannes, Robert L. Clark & Stefan Zauscher

  4. Department of Bioengineering and Chemical Engineering, UWEB, University of Washington, 98195, Seattle, Washington

    Buddy D. Ratner

Authors
  1. Angus Hucknall
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  2. Andrew J. Simnick
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  4. Ashutosh Chilkoti
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  5. Andres Garcia
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  6. Matthew S. Johannes
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  7. Robert L. Clark
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  8. Stefan Zauscher
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  9. Buddy D. Ratner
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Corresponding authors

Correspondence to Ashutosh Chilkoti or Stefan Zauscher.

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Hucknall, A., Simnick, A.J., Hill, R.T. et al. Versatile synthesis and micropatterning of nonfouling polymer brushes on the wafer scale. Biointerphases 4, FA50–FA57 (2009). https://doi.org/10.1116/1.3151968

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  • DOI: https://doi.org/10.1116/1.3151968