Biointerphases

Journal for Biophysical Chemistry

Biointerphases Cover Image
Open Access

Versatile synthesis and micropatterning of nonfouling polymer brushes on the wafer scale

  • Angus Hucknall1, 2,
  • Andrew J. Simnick1, 2,
  • Ryan T. Hill1, 2,
  • Ashutosh Chilkoti1, 2Email author,
  • Andres Garcia2, 3, 4,
  • Matthew S. Johannes2, 3, 5,
  • Robert L. Clark2, 3, 6,
  • Stefan Zauscher2, 3Email author and
  • Buddy D. Ratner7
Biointerphases4:40200050

https://doi.org/10.1116/1.3151968

Received: 24 April 2009

Accepted: 15 May 2009

Abstract

In this article, the authors describe new approaches to synthesize and pattern surfaces with poly[oligo(ethylene glycol) methyl methacrylate] (POEGMA) polymer brushes synthesized by surface-initiated atom transfer radical polymerization. These patterned coatings confer “nonfouling” properties protein and cell resistance—to the surface in a biological milieu. The versatile routes for the synthesis of POEGMA demonstrated here offer clear advantages over other techniques previously used in terms of their simplicity, reliability, and ability to pattern large-area substrates. They also demonstrate that POEGMA polymer brushes can be patterned directly by photolithography, plasma ashing, and reactive ion etching to create patterns at the micro- and nanoscale over large areas with high throughput and repeatability, while preserving the protein and cell resistance of the POEGMA brush.