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Biointerphases

Journal for Biophysical Chemistry

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Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers

Biointerphases volume 6, pages 33–42 (2011)Cite this article

Abstract

Polymer-based platforms in drug-eluting stents (DESs) can cause adverse reactions in patients. Hence, the development of a polymer-free drug delivery platform may reduce adverse reactions to DES. In this study, the use of a polymer-free platform, self-assembled monolayers (SAMs), is explored for delivering an antiproliferative drug [paclitaxel (PAT)] from a stent material [cobalt-chromium ((Co-Cr) alloy]. Initially, carboxylic acid terminated phosphonic acid SAMs were coated on Co-Cr alloy. Two different doses 25 and 100 μg/cm2) of PAT were coated on SAM coated Co-Cr surfaces using a microdrop deposition method. Also, control experiments were carried out to coat PAT directly on Co-Cr surfaces with no SAM modification. The PAT coated specimens were characterized using the Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and atomic force microscopy (AFM). FTIR spectra showed the successful deposition of PAT on SAM coated and control-Co-Cr surfaces. SEM images showed islands of high density PAT crystals on SAM coated surfaces, while low density PAT crystals were observed on control-Co-Cr alloy. AFM images showed molecular distribution of PAT on SAM coated as well as control-Co-Cr alloy surfaces. In vitro drug release studies showed that PAT was released from SAM coated Co-Cr surfaces in a biphasic manner (an initial burst release in first 7 days was followed by a slow release for up to 35 days), while the PAT was burst released from control-Co-Cr surfaces within 1–3 days. Thus, this study demonstrated the use of SAMs for delivering PAT from CouCr alloy surfaces for potential use in drug-eluting stents. ©2011 American Vacuum Society.

References

  1. P. Brubaker, M. Whaley, and L. Kaminsky, Coronary Artery Disease: Essentials of Prevention and Rehab Programs (Human Kinetics, Champaign, 2001).

    Google Scholar 

  2. G. Dorros and S. H. Stertzer, Appl. Radiol. 12, 69 (1983).

    CAS  Google Scholar 

  3. A. R. Wilson and J. C. Fuchs, Surg. Clin. North Am. 64, 121 (1984).

    CAS  Google Scholar 

  4. P. W. Serruys et al., N. Engl. J. Med. 331, 489 (1994).

    Article  CAS  Google Scholar 

  5. D. L. Fischman et al., N. Engl. J. Med. 331, 496 (1994).

    Article  CAS  Google Scholar 

  6. N. Kipshidze, G. Dangas, M. Tsapenko, J. Moses, M. B. Leon, M. Kutryk, and P. Serruys, J. Am. Coll. Cardiol. 44, 733 (2004).

    CAS  Google Scholar 

  7. A. C. Newby and A. B. Zaltsman, J. Pathol. 190, 300 (2000).

    Article  CAS  Google Scholar 

  8. C. R. Narins and S. G. Ellis, Semin Interv Cardiol. 3, 91 (1998).

    CAS  Google Scholar 

  9. S. Garg and P. W. Serruys, J. Am. Coll. Cardiol. 56, S1 (2010).

    Google Scholar 

  10. S. Garg and P. W. Serruys, J. Am. Coll. Cardiol. 56, S43 (2010).

    Google Scholar 

  11. Y. Otsuka, N. Chronos, R. Apkarian, and K. Robinson, J. Invasive Cardiol. 19, 71 (2007).

    Google Scholar 

  12. R. Virmani et al., Circulation 109, 701 (2004).

    Article  Google Scholar 

  13. R. Virmani, F. Kolodgie, and A. Farb, Am. Heart Hosp. J. 2, 85 (2004).

    Article  Google Scholar 

  14. R. Virmani, A. Farb, G. Guagliumi, and F. Kolodgie, Coron. Artery Dis. 15, 313 (2004).

    Article  Google Scholar 

  15. J. R. Nebeker et al., J. Am. Coll. Cardiol. 47, 175 (2006).

    Article  Google Scholar 

  16. G. Mani, M. D. Feldman, D. Patel, and C. M. Agrawal, Biomaterials 28, 1689 (2007).

    Article  CAS  Google Scholar 

  17. E. P. McFadden et al., Lancet 364, 1519 (2004).

    Article  CAS  Google Scholar 

  18. I. Iakovou et al., JAMA, J. Am. Med. Assoc. 293, 2126 (2005)

    Article  CAS  Google Scholar 

  19. A. T. L. Ong, E. P. McFadden, E. Regar, P. P. T. de Jaegere, R. T. van Domburg, and P. W. Serruys, J. Am. Coll. Cardiol. 45, 2088 (2005).

    Article  CAS  Google Scholar 

  20. M. Joner et al., J. Am. Coll. Cardiol. 48, 193 (2006).

    Article  Google Scholar 

  21. A. V. Finn, G. Nakazawa, M. Joner, F. D. Kolodgie, E. K. Mont, H. K. Gold, and R. Virmani, Arterioscler., Thromb., Vasc. Biol. 27, 1500 (2007).

    Article  CAS  Google Scholar 

  22. G. Mani, D. M. Johnson, D. Marton, M. D. Feldman, D. Patel, A. Ayon, and C. M. Agrawal, Biomaterials 29, 4561 (2008).

    Article  CAS  Google Scholar 

  23. G. Mani, B. Chandrasekar, M. D. Feldman, D. Patel, and C. M. Agrawal, J. Biomed. Mater. Res., Part B: Appl. Biomater. 90B, 789 (2009).

    Article  CAS  Google Scholar 

  24. G. Mani, C. E. Macias, M. D. Feldman, D. Marton, S. Oh, and C. M. Agrawal, Biomaterials 31, 5372 (2010).

    Article  CAS  Google Scholar 

  25. L. Sipos, A. Som, R. Faust, R. Richard, M. Schwarz, S. Ranade, M. Boden, and K. Chan, Biomacromolecules 6, 2570 (2005).

    Article  CAS  Google Scholar 

  26. T. G. Kim, H. Lee, Y. Jang, and T. G. Park, Biomacromolecules 10, 1532 (2009).

    Article  CAS  Google Scholar 

  27. H. J. Lim, H. Y. Nam, B. H. Lee, D. J. Kim, J. Y. Ko, and J. S. Park, Biotechnol. Prog. 23, 693 (2007).

    Article  CAS  Google Scholar 

  28. F. Innocente et al., Circulation 120, S37 (2009).

    Google Scholar 

  29. D. Song, L. F. Hsu, and J. L. Au, J. Pharm. Sci. 85, 29 (1996).

    Article  CAS  Google Scholar 

  30. J. J. Palmgren, J. Monkkonen, T. Korjamo, A. Hassinen, and S. Auriola, Eur. J. Pharm. Biopharm. 64, 369 (2006).

    Article  CAS  Google Scholar 

  31. D. V. Kilpadi, G. N. Raikar, J. Liu, J. E. Lemons, Y. Vohra, and J. C. Gregory, J. Biomed. Mater. Res. 40, 646 (1998).

    Article  CAS  Google Scholar 

  32. N. Adden, L. J. Gamble, D. G. Castner, A. Hoffmann, G. Gross, and H. Menzel, Langmuir 22, 8197 (2006).

    Article  CAS  Google Scholar 

  33. G. Mani, M. D. Feldman, S. Oh, and C. M. Agrawal, Appl. Surf. Sci. 255, 5961 (2009).

    Article  CAS  Google Scholar 

  34. A. Nanci, J. D. Wuest, L. Peru, P. Brunet, V. Sharma, S. Zalzal, and M. D. McKee, J. Biomed. Mater. Res. 40, 324 (1998).

    Article  CAS  Google Scholar 

  35. G. Mani, D. Johnson, D. Marton, V. L. Dougherty, M. D. Feldman, D. Patel, A. Ayon, and C. M. Agrawal, Langmuir 24, 6774 (2008).

    Article  CAS  Google Scholar 

  36. C. R. Kaufmann, G. Mani, D. Marton, D. M. Johnson, and C. M. Agrawal, Biomed. Mater. 5, 025008 (2010).

    Article  CAS  Google Scholar 

  37. A. Raman, M. Dubey, I. Gouzman, and E. S. Gawalt, Langmuir 22, 6469 (2006).

    Article  CAS  Google Scholar 

  38. A. Raman and E. S. Gawalt, Langmuir 23, 2284 (2007).

    Article  CAS  Google Scholar 

  39. R. Quiñones and E. S. Gawalt, Langmuir 23, 10123 (2007).

    Article  Google Scholar 

  40. A. Raman, R. Quinones, L. Barriger, R. Eastman, A. Parsi, and E. S. Gawalt, Langmuir 26, 1747 (2010).

    Article  CAS  Google Scholar 

  41. E. Suleymanoglu, Electron J Biomed. 3, 19 (2009).

    Google Scholar 

  42. A. B. Dhanikula and R. Panchagnula, Curr. Drug Deliv. 2, 75 (2005).

    Article  CAS  Google Scholar 

  43. R. T. Liggins, W. L. Hunter, and H. M. Burt, J. Pharm. Sci. 86, 1458 (1997).

    Article  CAS  Google Scholar 

  44. E. S. Gawalt, M. J. Avaltroni, N. Koch, and J. Schwartz, Langmuir 17, 5736 (2001).

    Article  CAS  Google Scholar 

  45. K. Kamath, J. J. Barry, and K. M. Miller, Adv. Drug Delivery Rev. 58, 412 (2006).

    Article  CAS  Google Scholar 

  46. A. König, M. Leibig, J. Rieber, T. M. Schiele, K. Theisen, U. Siebert, R. M. Gothe, and V. Klauss, Am. Heart J. 153, 979 (2007).

    Article  Google Scholar 

  47. D. Mastropaolo, A. Camerman, Y. Luo, G. D. Brayer, and N. Camerman, Proc. Natl. Acad. Sci. U.S.A. 92, 6920 (1995).

    Article  CAS  Google Scholar 

  48. I. H. Lee, Y. T. Park, K. Roh, H. Chung, I. C. Kwon, and S. Y. Jeong, J. Controlled Release 102, 415 (2005).

    Article  CAS  Google Scholar 

  49. S. Kim, J. Y. Kim, K. M. Huh, G. Acharya, and K. Park, J. Controlled Release 132, 222 (2008).

    Article  CAS  Google Scholar 

  50. H. S. Lim, J. N. BeMiller, and S. T. Lim, Cereal Chem. 80, 198 (2003).

    Article  CAS  Google Scholar 

  51. K. Kumeta, I. Nagashima, S. Matsui, and K. Mizoguchi, J. Appl. Polym. Sci. 90, 2420 (2003).

    Article  CAS  Google Scholar 

  52. R. Silva, E. C. Muniz, and A. F. Rubira, Polymer 49, 4066 (2008).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Biomedical Engineering Program, University of South Dakota, Sioux Falls, South Dakota, 57107, USA

    Gopinath Mani

  2. Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas, 78249, USA

    Nelson Torres & Sunho Oh

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  1. Gopinath Mani
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  2. Nelson Torres
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  3. Sunho Oh
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Mani, G., Torres, N. & Oh, S. Paclitaxel delivery from cobalt-chromium alloy surfaces using self-assembled monolayers. Biointerphases 6, 33–42 (2011). https://doi.org/10.1116/1.3575530

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  • DOI: https://doi.org/10.1116/1.3575530