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Journal for Biophysical Chemistry

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Immobilization of mycotoxins on modified nanodiamond substrates

Biointerphases volume 6, pages210–217(2011)Cite this article

Abstract

The effectiveness of modified nanodiamonds (NDs) for the adsorption of mycotoxins, aflatoxin B1 (AfB1) and ochratoxin A (OTA), are investigated in this paper. Binding and release mechanisms of the mycotoxins were addressed using an assortment of NDs modified by different surface treatments, including carboxylation, hydrogenation and hydroxylation, followed by isolating NDs of different sizes. Results indicate that AfB1 adsorption on NDs is directly related to aggregate size, whereas OTA adsorption is primarily centered upon electrostatic interactions that depend on the types of surface functional groups on the ND. Findings show that modified NDs with small aggregation sizes (~40 nm) have greater adsorption capacities for AfB1 than yeast cells walls and untreated NDs from various vendors, but comparable to activated charcoal. In OTA studies, positively charged NDs outperformed clay minerals, which are well-known and efficient sorbents for mycotoxins. Furthermore, ND adsorption capacities can be preserved in a wide range of pH.

Literatur

  1. 1

    G. Devegowda, B. I. R. Aravind and M. G. Morton, Australian Poultry Science Symposium, University of Sydney, Sydney, NSW, Australia, 1996 (unpublished), Vol. 8, 103–106.

    Google Scholar 

  2. 2

    F. Galvano, A. Ritieni, and G. Galvano, J. Food Prot. 64, 120 (2001).

    CAS  Google Scholar 

  3. 3

    A. J. Ramos and E. Hernandez, Anim. Feed Sci. and Technol. 62, 263 (1996).

    CAS  Article  Google Scholar 

  4. 4

    A. J. Ramos, J. Fink-Gremmels, and E. Hernandez, J. Food Prot. 59, 631 (1996).

    CAS  Google Scholar 

  5. 5

    W. L. Bryden, Asia Pac. J. Clin. Nutr. 16, 95 (2007).

    CAS  Google Scholar 

  6. 6

    S. Gradelet, A. M. LeBron, R. Berges, M. Suschetet, and P. Astorg, Carcinogenesis 19, 403 (1998).

    CAS  Article  Google Scholar 

  7. 7

    S. Gradelet, P. Astorg, A. M. LeBron, R. Berges, and M. Suschetet, Cancer Lett. 114, 223 (1997).

    Article  Google Scholar 

  8. 8

    H. S. Hussein and J. M. Brasel, Toxicology 167, 101 (2001).

    CAS  Article  Google Scholar 

  9. 9

    R. A. Squire, Science. 214, 877 (1981).

    CAS  Article  Google Scholar 

  10. 10

    C. V. Rensburg, “The Ameliorating Effect of Oxihumate on Aflatoxicosis in Broilers,” in Animal and Wildlife Sciences (University of Pretoria, Pretoria, 2005).

    Google Scholar 

  11. 11

    A. M. Wood, “Fungal Diseases,” in Poultry Diseases (Elsevier, New York, 2008) p. 428.

    Google Scholar 

  12. 12

    M. E. Smela, S. S. Currier, E. A. Bailey, and J. M. Essigmann, Carcinogenesis 22, 535 (2001).

    CAS  Article  Google Scholar 

  13. 13

    F. P. Guengericha, W. W. Johnson, T. Shimada, Y. F. Ueng, H. Yamazaki, and S. Langouet, Mutat. Res. 402, 121 (1998).

    Article  Google Scholar 

  14. 14

    V. M. Raney, T. M. Harris, and M. P. Chem. Res. Toxicol. 6, 64 (1993).

    CAS  Article  Google Scholar 

  15. 15

    C. C. Harris, Carcinogenesis 10, 1563 (1989).

    CAS  Article  Google Scholar 

  16. 16

    J. I. Pitt, Med. Mycol. 38, 41 (2000).

    CAS  Google Scholar 

  17. 17

    M. Denli and J. F. Perez, Toxins 2, 1065 (2010).

    CAS  Article  Google Scholar 

  18. 18

    International Program of Chemical Safety, Selected Mycotoxins: Ochratoxins, tricothecenes, ergot., Environmental Health Criteria 105, World Health Organization, Geneva, 1990, http://www.inchem.org/documents/ehc/ehc/ehc105.htm.

  19. 19

    A. Breitholtz-Emanuelsson, M. Olsen, A. Oskarsson, I. Palminger, and K. Hult. J. AOAC Int. 76, 842 (1993).

    CAS  Google Scholar 

  20. 20

    M. Miraglia, M. A. DeDominicis, C. Brera, S. Conrneli, E. Cava, E. Menghetti, and E. Miraslia, Nat. Toxins. 3, 436 (1995).

    CAS  Article  Google Scholar 

  21. 21

    P. A. Murphy, P. A. S. Hendrich, C. Landgren, and C. M. Bryant, J. Food Sci. Technol. 71, 51 (2006).

    Google Scholar 

  22. 22

    E. O'Brien and D. R. Dietrich, Crit. Rev. Toxicol. 35, 33 (2005).

    Article  Google Scholar 

  23. 23

    J. M. Soriano, H. Berrada, J. Blesa, J. C. Moltó and J. Mañes, New Issues in Food Policy, Control and Research (Nova Science, New York, 2007).

    Google Scholar 

  24. 24

    H. N. Mishra and C. Das, Crit. Rev. Food Sci Nutri. 43, 245 (2003).

    CAS  Article  Google Scholar 

  25. 25

    J. Varga, S. Kocsube, Z. Peteri, C. Vagvolgyi, and B. Toth, Toxins 2, 1718 (2010).

    CAS  Article  Google Scholar 

  26. 26

    P. M. Scott, Food Addit. Contam. 13, 19 (1996).

    CAS  Article  Google Scholar 

  27. 27

    M. Peraica, A. M. Domijan, Z. Jurjevic, and B. Cvjetkovic, Arh. Hig. Rada. Toksikol. 53, 229 (2002).

    CAS  Google Scholar 

  28. 28

    T. Edrington, S. L. F. Kubena, R. B. Harvey, and G. E. Rottinghaus, Poult. Sci. 76, 1205 (1997).

    CAS  Google Scholar 

  29. 29

    N. Gibson, O. Shenderova, T. J. M. Luo, S. Moseenkov, V. Bondar, A. Puzyr, K. Purtov, Z. Fitzgerald, and D. W. Brenner, Diamond Relat. Mater. 18, 620 (2009).

    CAS  Article  Google Scholar 

  30. 30

    A. P. Puzyr, K. V. Purtov, O. A. Shenderova, M. Luo, D. W. Brenner. and V. S. Bondar, Doklady Biochem. Biophys. 417, 299 (2007).

    CAS  Article  Google Scholar 

  31. 31

    A. M. Schrand, S. A. C. Hens and O. A. Shenderova, CRC Crit. Rev. Solid State Mater. Sci. 34, 18 (2009).

    CAS  Article  Google Scholar 

  32. 32

    A. M. Schrand, L. Dai, J. J. Schlager, S. M. Hussain, and E. Osawa, Diamond Relat. Mater. 16, 2118 (2007).

    CAS  Article  Google Scholar 

  33. 33

    A. P. Puzyr, V. S. Bondar and S. E. Al, Siberian Med. Obozrenie (Siberian Med. Rev.) (in Russian) 4, 19 (2004).

    Google Scholar 

  34. 34

    N. M. Gibson, T. J. M. Luo, O. Shenderova, Y. J. Choi, Z. Fitzgerald, and D. W. Brenner, Diamond Relat. Mater. 19, 234 (2010).

    CAS  Article  Google Scholar 

  35. 35

    N. M. Gibson, T. J. M. Luo, O. Shenderova, Y. J. Choi and D. W. Brenner. MRS Fall 2009 Proceedings, Report No. 1236-SS09-05, 2010.

    Google Scholar 

  36. 36

    G. N. Yushin, S. Osswald, V. I. Padalko, G. P. Bogatyreva, Y. Gogotsi, Diamond Relat. Mater. 47, 1721 (2005).

    Article  Google Scholar 

  37. 37

    S. Hens, G. Cunningham, T. Tyler, S. Moseenkov, V. Kuznetsov, and O. Shenderova, Diamond Relat. Mater. 17, 1858 (2008).

    CAS  Article  Google Scholar 

  38. 40

    T. D. Phillips, E. Afriyie-Gyawu, J. Williams, H. Huebner, N. A. Ankrah, D. Ofori-Adjei, P. Jolly, N. Johnson, J. Taylor, A. Marroquin-Cardona, L. Xu, L. Tang, and J. S. Wang, Food Addit. Contam. 25, 134 (2008).

    CAS  Article  Google Scholar 

  39. 41

    P. G. Grant and T. D. Phillips, J. Agric. Food Chem. 46, 599 (1998).

    CAS  Article  Google Scholar 

  40. 42

    R. Pachter and P. S. Steyn, Mutat. Res. 143, 87 (1985).

    CAS  Article  Google Scholar 

  41. 43

    R. Balasubramanian, S. V. Perumal, and K. Vijayaraghava. Ind. Eng. Chem. Res. 48, 2093 (2009).

    CAS  Article  Google Scholar 

  42. 44

    O. Sukand, R. Sukand, A. Magirin, and T. Tenno, Environ. Sci. Pollut. Res. 9, 43 (2002).

    Article  Google Scholar 

  43. 45

    A. Huwig, S. Freimund, O. Kappeli, and H. Dutler, Toxicolog. Lett. 122, 178 (2001).

    Google Scholar 

  44. 46

    K. A. Dawson, J. Evans, and M. Kudupoje, Sci. Technol. Feed Ind., 169, 2001.

    Google Scholar 

  45. 47

    M. Moschini, A. Gallo, G. Piva, and F. Masoero, Anim. Feed Sci. Technol. 147, 292 (2008).

    CAS  Article  Google Scholar 

  46. 48

    W. J. Decker and D. G. Corby, Vet. Hum. Toxicol. 22, 388 (1980).

    CAS  Google Scholar 

  47. 49

    D. Ringot, B. Lerzy, K. Chaplain, J. P. Bonhoure, E. Auclair, and Y. Larondelle, Biores. Technol. 98, 1812 (2007).

    CAS  Article  Google Scholar 

  48. 50

    I. Petrov, O. Shenderova, V. Grishko, V. Grichko, T. Tyler, G. Cunningham, and G. McGuire, Diamond. Relat. Mater. 16, 12 (2007).

    Article  Google Scholar 

  49. 51

    C. H. Giles, D. Smith, and A. Huitson, J. Colloid Interface Sci. 47, 755 (2974).

    Article  Google Scholar 

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Affiliations

  1. Department of Materials Science and Engineering, North Carolina State University, 911 Partners Way, Raleigh, North Carolina, 27695, USA

    N. M. Gibson, T. J. M. Luo & D. W. Brenner

  2. International Technology Center, P.O. Box 13740, Research Triangle Park, North Carolina, 27709, USA

    O. Shenderova

Authors
  1. N. M. Gibson
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  2. T. J. M. Luo
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  3. D. W. Brenner
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  4. O. Shenderova
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Correspondence to T. J. M. Luo.

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Gibson, N.M., Luo, T.J.M., Brenner, D.W. et al. Immobilization of mycotoxins on modified nanodiamond substrates. Biointerphases 6, 210–217 (2011). https://doi.org/10.1116/1.3672489

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