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Biointerphases

Journal for Biophysical Chemistry

Figure 1 | Biointerphases

Figure 1

From: ToF-SIMS analysis of osteoblast-like cells and their mineralized extracellular matrix on strontium enriched bone cements

Figure 1

Mass spectra (A1 and A2), optical image (B) and SIMS mass images (C-E) of strontium substituted calcium phosphate cement cultured with hMSCs in osteogenic differentiation medium for one day (S100 1d). Figure A1 shows the labeled masses which were used to generated the SIMS mass images. A typical mass pattern of the strontium isotopes is shown in Figure A2. The spatial distribution of the cell mass signals (C), calcium signals (D) and strontium signals (E) are shown in the SIMS mass images. The spatial patterns of mass signals offer the same morphological information as the microscope image (B), in which the cells are shown in white and the S100 cement in grey.

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