Figure 6

Representative positive-ion ToF-SIMS spectra of (a) HV-treated and (b) dehydrated collagen fibril matrices. Spectra were collected well below the static limit (< 10¹² ions/cm²). Spectra were calibrated using the CH₃ ⁺, C₂H₃ ⁺, C₃H₅ ⁺, and C₇H₇ ⁺ fragments. The H₃O⁺ is annotated (*) to illustrate that the yields in both samples were similar, and that no signal enhancement due to water was present in the spectrum of the HV-treated fibril matrix. The ion dose was held constant for all samples, and both spectra had total secondary ion counts of approximately 1.2 × 10⁷.