Citation: Biointerphases 2012 7:68
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Polythiophene Synthesis Coupled to Quartz Crystal Microbalance and Raman Spectroscopy for Detecting Bacteria
A simple electrochemical procedure was used for the synthesis of a polythiophene containingpara-benzenesulfonyl chloride groups. The obtained polymer was shown to be very reactive and directly able to covalently ...
Citation: Biointerphases 2012 7:67
How to Control the Recombinant Prion Protein Adhesion for Successful Storage Through Modification of Surface Properties
Depletion of neuroproteins on the inner walls of storage tubes influences the accuracy of tests used for identification of various neurodegenerative disorders. In this paper, a strategy is described for surfac...
Citation: Biointerphases 2012 7:66
Selective Cell Recruitment and Spatially Controlled Cell Attachment on Instructive Chitosan Surfaces Functionalized with Antibodies
Bioactive constructs to guide cellular mobilization and function have been proposed as an approach for a new generation of biomaterials in functional tissue engineering. Adult mesenchymal stem cells have been ...
Citation: Biointerphases 2012 7:65
This review article summarizes some recent insights into the strategies used by marine organisms to select surfaces for colonization. While larger organisms rely on their sensory machinery to select surfaces, ...
Citation: Biointerphases 2012 7:63
Investigations on the Secondary Structure of Polypeptide Chains in Polyelectrolyte Multilayers and their Effect on the Adhesion and Spreading of Osteoblasts
Inspired by the composition of the native extracellular matrix, biomimetic polyelectrolyte multilayers were assembled from polypeptides and the glycosaminoglycan chondroitin sulfate (CS). To investigate whethe...
Citation: Biointerphases 2012 7:62
Surface Functionalized Nanofibrillar Cellulose (NFC) Film as a Platform for Immunoassays and Diagnostics
We introduce a new method to modify films of nanofibrillated cellulose (NFC) to produce non-porous, water-resistant substrates for diagnostics. First, water resistant NFC films were prepared from mechanically ...
Citation: Biointerphases 2012 7:61
Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition
Cathodic arc deposition technique was used to deposit zirconia (ZrO2) films and titania (TiO2) films on titanium (Ti) disks respectively. The surface topography was characterized by scanning electron microscopy a...
Citation: Biointerphases 2012 7:60
Changes in Permeability and in Mechanical Properties of Layer-by-Layer Films Made from Poly(allylamine) and Montmorillonite Postmodified upon Reaction with Dopamine
Polyelectrolyte multilayer (PEM) films present a versatile surface functionalization method allowing to address many applications. These coatings suffer; however, from weak mechanical properties this problem c...
Citation: Biointerphases 2012 7:59
Low impedance at the interface between tissue and conducting electrodes is of utmost importance for the electrical recording or stimulation of heart and brain tissue. A common way to improve the cell–metal int...
Citation: Biointerphases 2012 7:58
We synthesized nano-scaled periodic ripple patterns on silicon and titanium dioxide (TiO2) surfaces by xenon ion irradiation, and performed adsorption experiments with human plasma fibrinogen (HPF) on such surfac...
Citation: Biointerphases 2012 7:55
Micrometer and Nanometer Scale Photopatterning of Proteins on Glass Surfaces by Photo-degradation of Films Formed from Oligo(Ethylene Glycol) Terminated Silanes
Exposure of films formed by the adsorption of oligo(ethylene glycol) (OEG) functionalized trichlorosilanes on glass to UV light from a frequency-doubled argon ion laser (244 nm) causes photodegradation of the ...
Citation: Biointerphases 2012 7:54
Development of a Tuned Interfacial Force Field Parameter Set for the Simulation of Protein Adsorption to Silica Glass
Adsorption free energies for eight host–guest peptides (TGTG-X-GTGT, with X = N, D, G, K, F, T, W, and V) on two different silica surfaces [quartz (100) and silica glass] were calculated using umbrella samplin...
Citation: Biointerphases 2012 7:56
Computer Simulation of Water-Mediated Adhesion Between Phospholipid Bilayer and Solid Support Functionalized with Self-Assembled Monolayers
An attempt is made to estimate, via computer simulation of the force–distance relation, the free energy of adhesion between a phosphatidylethanolamine bilayer and an alkanethiolate self-assembled monolayer (SA...
Citation: Biointerphases 2012 7:57
We present the design and use of an ultrathin, stretchable sensor system capable of conformal lamination onto the skin, for precision measurement and spatial mapping of levels of hydration. This device, which ...
Citation: Biointerphases 2012 7:52
Surface exploration is a key step in the colonization of surfaces by sessile marine biofoulers. As many biofouling organisms can delay settlement until a suitable surface is encountered, colonization can compr...
Citation: Biointerphases 2012 7:50
To successfully apply implant materials for regenerative processes in the body, understanding the mechanisms at the interface between cells or tissues and the artificial material is of critical importance. Thi...
Citation: Biointerphases 2012 7:51
The use of multivariate analysis (MVA) methods in the processing of time-of-flight secondary ion mass spectrometry (ToF-SIMS) data has become increasingly more common. MVA presents a powerful set of tools to a...
Citation: Biointerphases 2012 7:49
The intent to solve biological and biomedical questions in high-throughput led to an immense interest in microarray technologies. Nowadays, DNA microarrays are routinely used to screen for oligonucleotide inte...
Citation: Biointerphases 2012 7:47
Reversible Changes in Cell Morphology due to Cytoskeletal Rearrangements Measured in Real-Time by QCM-D
The mechanical properties and responses of cells to external stimuli (including drugs) are closely connected to important phenomena such as cell spreading, motility, activity, and potentially even differentiat...
Citation: Biointerphases 2012 7:43
Many plant tissues and organs are capable of moving due to changes in the humidity of the environment, such as the opening of the seed capsule of the ice plant and the opening of the pine cone. These are fasci...
Citation: Biointerphases 2012 7:42
In this study, we compared the structural and physicochemical properties of different concentrations of alginate and high molecular weight hyaluronic acid (HA) hydrogels and their biocompatibility and bioactiv...
Citation: Biointerphases 2012 7:44
Correlations Between the Biochemistry and Mechanical States of a Sea-Urchin Ligament: A Mutable Collagenous Structure
Mutable collagenous tissues (MCTs) of echinoderms can be regarded as intelligent and dynamic biomaterials, due to their ability to reversibly change their mechanical properties in a short physiological time sp...
Citation: Biointerphases 2012 7:38
Bioactive Glass 45S5 Powders: Effect of Synthesis Route and Resultant Surface Chemistry and Crystallinity on Protein Adsorption from Human Plasma
Despite its medical applications, the mechanisms responsible for the osseointegration of bioactive glass (45S5) have yet to be fully understood. Evidence suggests that the strongest predictor for osseointegrat...
Citation: Biointerphases 2012 7:41
Cells behave differently between bidimensional (2D) and tridimensional (3D) environments. While most of the in vitro cultures are 2D, most of the in vivo extracellular matrices are 3D, which encourages the dev...
Citation: Biointerphases 2012 7:39
Although it is well known that the textural properties of scaffolds play an important role in the process of tissue regeneration, the investigation of such effects remain difficult especially at the micro/nano...
Citation: Biointerphases 2012 7:37
Osteoclasts are responsible for bone resorption and implant surface roughness promotes osseointegration. However, little is known about the effect of roughness on osteoclast activity. This study aims at the ch...
Citation: Biointerphases 2012 7:34
The aim was to compare the protein release from normal human osteoblasts (NHO) cultured on scaffolds with similar morphology but different coatings. Different ceramic coatings; TiO2, SiO2 and calcium phosphate (C...
Citation: Biointerphases 2012 7:36
Settlement Behavior of Zoospores of Ulva linza During Surface Selection Studied by Digital Holographic Microscopy
Settlement of the planktonic dispersal stages of marine organisms is the crucial step for the development of marine biofouling. Four-dimensional holographic tracking reveals the mechanism by which algal spores...
Citation: Biointerphases 2012 7:33
Evaluation of Protein Adsorption on Atmospheric Plasma Deposited Coatings Exhibiting Superhydrophilic to Superhydrophobic Properties
Protein adsorption is one of the key parameters influencing the biocompatibility of medical device materials. This study investigates serum protein adsorption and bacterial attachment on polymer coatings depos...
Citation: Biointerphases 2012 7:31
Immobilization of Gelatin onto Poly(Glycidyl Methacrylate)-Grafted Polycaprolactone Substrates for Improved Cell–Material Interactions
To enhance the cytocompatibility of polycaprolactone (PCL), cell-adhesive gelatin is covalently immobilized onto the PCL film surface via two surface-modified approaches: a conventional chemical immobilization...
Citation: Biointerphases 2012 7:30
Surface ion equilibrium is hypothesized to play an important role in defining the interactions between foreign materials and biological systems. In this study, we compare two surfaces with respect to their abi...
Citation: Biointerphases 2012 7:28
Effect of Titanium Surface Calcium and Magnesium on Adhesive Activity of Epithelial-Like Cells and Fibroblasts
In the present study, we investigated the hydrothermal treatment of titanium with divalent cation solutions and its effect in promoting the adhesion of gingival epithelial cells and fibroblasts in vitro. Gingi...
Citation: Biointerphases 2012 7:27
For both, environmental and medical applications, the quantification of bacterial adhesion is of major importance to understand and support the development of new materials. For marine applications, the demand...
Citation: Biointerphases 2012 7:26
Type-I collagen is an attractive scaffold material for tissue engineering due to its ability to self-assemble into a fibrillar hydrogel, its innate support of tissue cells through bioactive adhesion sites, and...
Citation: Biointerphases 2012 7:25
Oriented, Multimeric Biointerfaces of the L1 Cell Adhesion Molecule: An Approach to Enhance Neuronal and Neural Stem Cell Functions on 2-D and 3-D Polymer Substrates
This article focuses on elucidating the key presentation features of neurotrophic ligands at polymer interfaces. Different biointerfacial configurations of the human neural cell adhesion molecule L1 were estab...
Citation: Biointerphases 2012 7:22
Substrates coated with specific bioactive ligands are important for tissue engineering, enabling the local presentation of extracellular stimulants at controlled positions and densities. In this study, we exam...
Citation: Biointerphases 2012 7:23
Comparison Between Empirical Protein Force Fields for the Simulation of the Adsorption Behavior of Structured LK Peptides on Functionalized Surfaces
All-atom empirical molecular mechanics protein force fields, which have been developed to represent the energetics of peptide folding behavior in aqueous solution, have not been parameterized for protein inter...
Citation: Biointerphases 2012 7:24
Proliferation of Epithelial Cells on PDMS Substrates with Micropillars Fabricated with Different Curvature Characteristics
The present work studied the proliferation of epithelial cells when they were cultivated on substrates with micropillars fabricated with the same height but with different curvature characteristics. A special ...
Citation: Biointerphases 2012 7:21
The surface vibrational spectrum of water at biological interfaces is often interpreted as having ‘ice-like’ and ‘liquid-like’ components. Here we show that the vibrational spectrum of water at both water–lipi...
Citation: Biointerphases 2012 7:20
The Role of Enamel Proteins in Protecting Mature Human Enamel Against Acidic Environments: A Double Layer Force Spectroscopy Study
Characterisation of the electrostatic properties of dental enamel is important for understanding the interfacial processes that occur on a tooth surface and how these relate to the natural ability of our teeth...
Citation: Biointerphases 2012 7:14
The New (Challenging) Role of Academia in Biomaterial Translational Research and Medical Device Development
With the ever-changing landscape of translational research, the medical device and pharmaceutical industries increasingly license technologies with the added value of clinical and/or pre-clinical data rather t...
Citation: Biointerphases 2012 7:12
Citation: Biointerphases 2012 7:15
Citation: Biointerphases 2012 7:19
As one of the most important interfaces in cellular systems, biological membranes have essential functions in many activities such as cellular protection and signaling. Beyond their direct functions, they also...
Citation: Biointerphases 2012 7:18
This review focuses on smart nano-materials built of stimuli-responsive (SR) polymers and will discuss their numerous applications in the biomedical field. The authors will first provide an overview of differe...
Citation: Biointerphases 2012 7:9
The fabrication of tissue engineering scaffolds is a well-established field that has gained recent prominence for the in vivo repair of a variety of tissue types. Recently, increasing levels of sophistication ...
Citation: Biointerphases 2012 7:2
Polyethylenimine-Based Amphiphilic Core–Shell Nanoparticles: Study of Gene Delivery and Intracellular Trafficking
Amphiphilic core–shell nanoparticle, which is composed of a hydrophobic core and a branched polyethylenimine (PEI) shell, has been designed and synthesized as a novel gene delivery nanocarrier. In our previous...
Citation: Biointerphases 2012 7:16
Using variothermal polymer micro-injection molding, disposable arrays of eight polymer micro-cantilevers each 500 μm long, 100 μm wide and 25 μm thick were fabricated. The present study took advantage of an e...
Citation: Biointerphases 2012 7:6
Alkylation of Spiropyran Moiety Provides Reversible Photo-Control over Nanostructured Soft Materials
The purpose of this study was to create a light responsive nanostructured liquid crystalline matrix using a novel alkylated spiropyran photochromic molecule (spiropyran laurate, SPL) as a light activated drug ...
Citation: Biointerphases 2012 7:3